Calbindin D9K Antibody (F-6): sc-74492

Calbindin D9K Antibody (F-6) is a mouse monoclonal IgG2a antibody that detects Calbindin D9K in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Calbindin D9K is a member of the EF-hand type calcium-binding protein family, which plays a crucial role in calcium homeostasis and signaling within cells. Anti-Calbindin D9K antibody (F-6) recognizes protein predominantly located in cartilage, bone, and specific dental tissues, such as the ameloblasts of incisors and molars, where Calbindin D9K is essential for the regulation of calcium levels during the development and maintenance of these structures. The presence of Calbindin D9K in the proximal small intestine further highlights its importance in calcium absorption and metabolism. The gene encoding human Calbindin D9K is situated on the X chromosome and features an estrogen response element, which is critical for regulation; however, the human sequence differs from that of rats, leading to a lack of binding to the estrogen receptor and suggesting a suppression of gene expression in certain human tissues, such as the uterus and placenta. This unique regulatory mechanism underscores the significance of Calbindin D9K in various physiological processes and potential implications in health and disease.

The preferred Calbindin D9K antibody is Calbindin D9K Antibody (D-5): sc-74462.