Cabin-1 Antibody (B-11): sc-514269

Cabin-1 Antibody (B-11) is a mouse monoclonal IgM antibody that detects Cabin-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Cabin-1 antibody (B-11) is available as the non-conjugated form. Cabin-1 protein, also known as calcineurin binding protein, plays a crucial role in regulating calcineurin activity, a serine/threonine phosphatase essential for T cell signaling and apoptosis. This regulation is particularly important because calcineurin is involved in transcriptional activation of various cytokines and transcription factors, including NFAT, NFkB, and AP-1, which are pivotal in T cell receptor-mediated signaling pathways. The interaction between Cabin-1 and calcineurin is influenced by intracellular calcium levels and protein kinase C activity; upon T cell receptor activation, protein kinase C induces hyperphosphorylation of Cabin-1, enhancing binding affinity to calcineurin. This binding forms a complex that inhibits calcineurin′s activity, thereby modulating T cell signaling. Cabin-1 also interacts with MEF-2 transcription factors, which are critical for regulating apoptosis in T cells. This interaction inhibits MEF-2-mediated gene transcription, further contributing to T cell apoptosis regulation. The multifaceted role of Cabin-1 in these signaling pathways underscores its importance in immune responses and potential implications in immunological disorders.

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Cabin-1 Antibody (B-11) References:

1. Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2.  |  Youn, HD., et al. 1999. Science. 286: 790-3. PMID: 10531067
2. Protein kinase ctheta cooperates with calcineurin to induce Fas ligand expression during activation-induced T cell death.  |  Villalba, M., et al. 1999. J Immunol. 163: 5813-9. PMID: 10570264
3. Protein serine/threonine phosphatases--new avenues for cell regulation.  |  Shenolikar, S. 1994. Annu Rev Cell Biol. 10: 55-86. PMID: 7888183
4. Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes.  |  Sun, L., et al. 1998. Immunity. 8: 703-11. PMID: 9655484
5. Cain, a novel physiologic protein inhibitor of calcineurin.  |  Lai, MM., et al. 1998. J Biol Chem. 273: 18325-31. PMID: 9660798
6. Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins.  |  Black, BL. and Olson, EN. 1998. Annu Rev Cell Dev Biol. 14: 167-96. PMID: 9891782

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Cabin-1 Antibody (B-11) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Cabin-1 Antibody (B-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Cabin-1 Antibody (B-11) Specifications

Alternate Product Name: Cabin-1

Product Clone Name: B-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 2169-2188

Epitope Target: Cabin-1

Epitope Species: human

Product Reactivity/Detection: Cabin-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Cabin-1 Antibody (B-11): P: Blocking Peptide