CA215 Antibody (RP 215): sc-69849

CA215 Antibody (RP 215) is a mouse monoclonal IgG1 kappa light chain antibody that detects CA215 by western blotting (WB) and immunofluorescence (IF). CA215 (RP 215) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CA215, also known as cancer antigen 215, plays a crucial role as a pan-cancer marker, being expressed on the surface of cancer cells derived from various tissues, including ovarian, cervical, breast, lung, stomach, colon, and esophagus. CA215 serves as a biomarker for the diagnosis and monitoring of different cancer types, providing valuable insights into tumor characteristics and potential therapeutic targets. CA215 is not only produced by B cells in a healthy immune system but has also been identified in hyperplastic epithelial cells and cancer cells, highlighting its importance in cancer biology. Anti-CA215 antibody (RP 215)′s ability to detect CA215 in various applications makes this reagent an essential tool for researchers studying cancer mechanisms and developing targeted therapies.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

CA215 Antibody (RP 215) References:

1. Glycoproteomic analyses of ovarian cancer cell lines and sera from ovarian cancer patients show distinct glycosylation changes in individual proteins.  |  Li, B., et al. 2008. J Proteome Res. 7: 3776-88. PMID: 18642944
2. Hereditary ovarian cancer.  |  Russo, A., et al. 2009. Crit Rev Oncol Hematol. 69: 28-44. PMID: 18656380
3. Molecular identity of a pan cancer marker, CA215.  |  Lee, G., et al. 2008. Cancer Biol Ther. 7: 2007-14. PMID: 19158477
4. Inhibition of in vitro tumor cell growth by RP215 monoclonal antibody and antibodies raised against its anti-idiotype antibodies.  |  Lee, G. and Ge, B. 2010. Cancer Immunol Immunother. 59: 1347-56. PMID: 20473495
5. Vaccination against tumor cells expressing breast cancer epithelial tumor antigen.  |  Hareuveni, M., et al. 1990. Proc Natl Acad Sci U S A. 87: 9498-502. PMID: 2251291
6. Aberrant high expression of immunoglobulin G in epithelial stem/progenitor-like cells contributes to tumor initiation and metastasis.  |  Liao, Q., et al. 2015. Oncotarget. 6: 40081-94. PMID: 26472025
7. Monoclonal antibodies against ovarian carcinoma-associated antigens, raised by immunization with cyst fluids.  |  Boerman, O., et al. 1989. Anticancer Res. 9: 551-8. PMID: 2764501
8. Co-stimulation with B7 and targeted superantigen is required for MHC class II-independent T-cell proliferation but not cytotoxicity.  |  Lando, PA., et al. 1993. Immunology. 80: 236-41. PMID: 7505257
9. Regulation of superantigen-induced T cell activation in the absence and the presence of MHC class II.  |  Lando, PA., et al. 1996. J Immunol. 157: 2857-63. PMID: 8816390
10. Chloramine-T in high-specific-activity radioiodination of antibodies using N-succinimidyl-3-(trimethylstannyl)benzoate as an intermediate.  |  Lindegren, S., et al. 1998. Nucl Med Biol. 25: 659-65. PMID: 9804047
11. MHC class II-independent, Vbeta-specific activation of T cells by superantigen mutants fused to anti-tumor Fab fragments: implications for use in treatment of human colon carcinoma.  |  Newton, DW., et al. 1998. Int J Mol Med. 1: 157-62. PMID: 9852214

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CA215 Antibody (RP 215) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-CA215 Antibody (RP 215) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CA215 Antibody (RP 215) Specifications

Alternate Product Name: CA215

Product Clone Name: RP 215

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target:

Epitope Species: human

Product Reactivity/Detection: carbohydrate-associated epitope(s) in the heavy chains of cancer cell-expressed immunoglobulins, designated in general as CA215 pan cancer marker

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for CA215 Antibody (RP 215): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin