CA IV Antibody (E-6): sc-390371
- CA IV Antibody (E-6) is a mouse monoclonal IgM κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 9-43 near the N-terminus of CA IV of human origin
- recommended for detection of CA IV of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CA IV Antibody (E-6). This work is in progress.
CA IV Antibody (E-6) is a mouse monoclonal IgM antibody that detects carbonic anhydrase IV (CA IV) in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). CA IV (E-6) antibody recognizes a glycosylphosphatidylinositol-anchored enzyme located on the outer surface of the plasma membrane, primarily found on the plasma face of microcapillaries and in the choriocapillaris of the human eye. This strategic localization allows CA IV to effectively catalyze the hydration and dehydration of carbon dioxide and bicarbonate, playing a vital role in maintaining acid-base balance and facilitating renal acidification in the kidney. CA IV (E-6) monoclonal antibody targets a protein involved in regulating interstitial pH transients in the brain, which is essential for proper neuronal function. Disruption in CA IV targeting can lead to impaired bicarbonate secretion, which is associated with dysfunction in cystic fibrosis cells. As a member of the carbonic anhydrase family, CA IV is a zinc metalloenzyme that contributes to various physiological processes, including respiration, calcification, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid, highlighting its importance in both health and disease.
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CA IV Antibody (E-6) References:
- Targeting of carbonic anhydrase IV to plasma membranes is altered in cultured human pancreatic duct cells expressing a mutated (deltaF508) CFTR. | Fanjul, M., et al. 2002. Eur J Cell Biol. 81: 437-47. PMID: 12234015
- Human carbonic anhydrase IV: cDNA cloning, sequence comparison, and expression in COS cell membranes. | Okuyama, T., et al. 1992. Proc Natl Acad Sci U S A. 89: 1315-9. PMID: 1311094
- Carbonic anhydrase IV on brain capillary endothelial cells: a marker associated with the blood-brain barrier. | Ghandour, MS., et al. 1992. Proc Natl Acad Sci U S A. 89: 6823-7. PMID: 1495971
- Role of carbonic anhydrase IV in corneal endothelial HCO3- transport. | Sun, XC., et al. 2008. Invest Ophthalmol Vis Sci. 49: 1048-55. PMID: 18326729
- Localization of carbonic anhydrase IV in a specific capillary bed of the human eye. | Hageman, GS., et al. 1991. Proc Natl Acad Sci U S A. 88: 2716-20. PMID: 1901414
- Membrane-bound carbonic anhydrase CA IV in the human kidney. | Lönnerholm, G. and Wistrand, PJ. 1991. Acta Physiol Scand. 141: 231-4. PMID: 1904675
- Carbonic anhydrase IV inhibits colon cancer development by inhibiting the Wnt signalling pathway through targeting the WTAP-WT1-TBL1 axis. | Zhang, J., et al. 2016. Gut. 65: 1482-93. PMID: 26071132
- Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV. | Mickevičiūtė, A., et al. 2018. Eur Biophys J. 47: 271-290. PMID: 28975383
- Chemical properties of carbonic anhydrase IV, the membrane-bound enzyme. | Maren, TH., et al. 1993. Mol Pharmacol. 44: 901-5. PMID: 8232240
- Pulmonary carbonic anhydrase IV: developmental regulation and cell-specific expression in the capillary endothelium. | Fleming, RE., et al. 1993. Am J Physiol. 265: L627-35. PMID: 8279579
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CA IV Antibody (E-6) | sc-390371 | 200 µg/ml | $322.00 | |||
CA IV (E-6) Neutralizing Peptide | sc-390371 P | 100 µg/0.5 ml | $69.00 |