C4ST-1 Antibody (L18): sc-100868

C4ST-1 Antibody (L18) is a mouse monoclonal IgG1 kappa light chain antibody that detects C4ST-1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-C4ST-1 antibody (L18) is available as the non-conjugated form. C4ST-1, also known as chondroitin 4-sulphotransferase-1, plays a crucial role in the sulfation of chondroitin, specifically transferring sulfate from adenosine 3′-phosphate 5′-phosphosulphate to the 4-O position of N-acetylgalactosamine. This post-translational modification is essential for proper localization of chondroitin sulfate, which modulates various signaling pathways and is vital for cartilage growth plate morphogenesis. The sulfation process facilitated by C4ST-1 is significant for maintaining structural integrity and function of cartilage, making C4ST-1 a key player in skeletal development and repair. Additionally, N-linked oligosaccharides attached to C4ST-1 enhance production and stability of active C4ST-1, further underscoring C4ST-1′s importance in physiological processes.

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C4ST-1 Antibody (L18) References:

1. Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family.  |  Hiraoka, N., et al. 2000. J Biol Chem. 275: 20188-96. PMID: 10781601
2. Molecular cloning and expression of the pituitary glycoprotein hormone N-acetylgalactosamine-4-O-sulfotransferase.  |  Xia, G., et al. 2000. J Biol Chem. 275: 38402-9. PMID: 10988300
3. Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis.  |  Mikami, T., et al. 2003. J Biol Chem. 278: 36115-27. PMID: 12847091
4. Chondroitin 4-sulphotransferase-1 and chondroitin 6-sulphotransferase-1 are affected differently by uronic acid residues neighbouring the acceptor GalNAc residues.  |  Yamada, T., et al. 2004. Biochem J. 384: 567-75. PMID: 15324304
5. N-linked oligosaccharides are required to produce and stabilize the active form of chondroitin 4-sulphotransferase-1.  |  Yusa, A., et al. 2005. Biochem J. 388: 115-21. PMID: 15628971
6. Maintenance of chondroitin sulfation balance by chondroitin-4-sulfotransferase 1 is required for chondrocyte development and growth factor signaling during cartilage morphogenesis.  |  Klüppel, M., et al. 2005. Development. 132: 3989-4003. PMID: 16079159
7. Regulation of the chondroitin/dermatan fine structure by transforming growth factor-beta1 through effects on polymer-modifying enzymes.  |  Tiedemann, K., et al. 2005. Glycobiology. 15: 1277-85. PMID: 16118286
8. Chondroitin sulfate/dermatan sulfate hybrid chains in the development of cerebellum. Spatiotemporal regulation of the expression of critical disulfated disaccharides by specific sulfotransferases.  |  Mitsunaga, C., et al. 2006. J Biol Chem. 281: 18942-52. PMID: 16702220

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-C4ST-1 Antibody (L18) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-C4ST-1 Antibody (L18) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

C4ST-1 Antibody (L18) Specifications

Alternate Product Name: C4ST-1

Product Clone Name: L18

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 230-338

Epitope Target: C4ST-1

Epitope Species: human

Product Reactivity/Detection: C4ST-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for C4ST-1 Antibody (L18): N/A