C4β Antibody (D-12): sc-74524

C4β Antibody (D-12) is a mouse monoclonal IgG2a kappa light chain antibody that detects C4β protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-C4β antibody (D-12) is available as the non-conjugated form. C4β protein plays a crucial role in the complement system, which is essential for immune defense and inflammation regulation. C4β protein is synthesized as a precursor that is cleaved into three chains: α, β, and γ, each with distinct functions. C4β (D-12) antibody recognizes the α chain that can be further processed into two isotypes, C4α and C4β, which differ in their reactivity with amino and hydroxyl groups, respectively. This structural diversity allows for specific interactions with various ligands, enhancing the complement system′s ability to target pathogens effectively. C4β protein variations are linked to different blood group antigens, which can influence individual susceptibility to autoimmune diseases. C4β protein deficiencies are associated with conditions such as systemic lupus erythematosus, highlighting C4β′s importance in maintaining immune homeostasis.

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C4β Antibody (D-12) References:

1. Genetic, structural and functional diversities of human complement components C4A and C4B and their mouse homologues, Slp and C4.  |  Blanchong, CA., et al. 2001. Int Immunopharmacol. 1: 365-92. PMID: 11367523
2. Genetics of human complement component C4 and evolution the central MHC.  |  Martinez, OP., et al. 2001. Front Biosci. 6: D904-13. PMID: 11487475
3. Characterization of a de novo conversion in human complement C4 gene producing a C4B5-like protein.  |  Jaatinen, T., et al. 2002. J Immunol. 168: 5652-8. PMID: 12023363
4. The molecular basis of complete complement C4A and C4B deficiencies in a systemic lupus erythematosus patient with homozygous C4A and C4B mutant genes.  |  Rupert, KL., et al. 2002. J Immunol. 169: 1570-8. PMID: 12133986
5. Studies on novel 4beta-[(4-substituted)-1,2,3-triazol-1-yl] podophyllotoxins as potential anticancer agents.  |  Bhat, BA., et al. 2008. Eur J Med Chem. 43: 2067-72. PMID: 17988764
6. Homology modeling and site-directed mutagenesis reveal catalytic key amino acids of 3beta-hydroxysteroid-dehydrogenase/C4-decarboxylase from Arabidopsis.  |  Rahier, A., et al. 2009. Plant Physiol. 149: 1872-86. PMID: 19218365
7. Structural basis of the polymorphism of human complement components C4A and C4B: gene size, reactivity and antigenicity.  |  Yu, CY., et al. 1986. EMBO J. 5: 2873-81. PMID: 2431902
8. Synthesis and pharmacological characterization of C4-disubstituted analogs of 1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: identification of a potent, selective metabotropic glutamate receptor agonist and determination of agonist-bound human mGlu2 and mGlu3 amino terminal domain structures.  |  Monn, JA., et al. 2015. J Med Chem. 58: 1776-94. PMID: 25602126
9. Low activity of complement in the cerebrospinal fluid of the patients with various prion diseases.  |  Chen, C., et al. 2016. Infect Dis Poverty. 5: 35. PMID: 27138196
10. Computational Analysis of the Selective Formation of the C4α-C8' Bond in the Intermolecular Coupling of Catechin Derivatives.  |  Fukaya, K., et al. 2020. J Org Chem. 85: 5010-5018. PMID: 32149508
11. Structure and function of the anaphylatoxins.  |  Hugli, TE. 1984. Springer Semin Immunopathol. 7: 193-219. PMID: 6387982
12. Molecular characterization of complement components (C3, C4, and factor B) in human saliva.  |  Andoh, A., et al. 1997. J Clin Immunol. 17: 404-7. PMID: 9327340

The preferred C4α antibody is C4α Antibody (C-2): sc-271181.