RWDD2B Antibody (D-4): sc-514511

RWDD2B Antibody (D-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects RWDD2B of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RWDD2B (D-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RWDD2B, also known as C21orf6, consists of 319 amino acids and is ubiquitously expressed across various tissues, highlighting its potential role in fundamental cellular processes. RWDD2B contains a single RWD domain, a conserved structural motif approximately 110 amino acids in length, which is implicated in mediating protein-protein interactions. RWD domains are found in a variety of proteins, including RING finger proteins and DEAD-like helicases, suggesting RWDD2B may play a critical role in cellular signaling pathways and regulatory mechanisms. RWDD2B is located on chromosome 21, a region associated with several genetic disorders, including Down syndrome, Alzheimer′s disease, and certain leukemias, underscoring the significance of RWDD2B in both health and disease.

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RWDD2B Antibody (D-4) References:

1. Molecular cytogenetic dissection of human chromosomes 3 and 21 evolution.  |  Müller, S., et al. 2000. Proc Natl Acad Sci U S A. 97: 206-11. PMID: 10618396
2. Characterization of a novel gene, C21orf6, mapping to a critical region of chromosome 21q22.1 involved in the monosomy 21 phenotype and of its murine ortholog, orf5.  |  Orti, R., et al. 2000. Genomics. 64: 203-10. PMID: 10729227
3. Systematic identification of novel protein domain families associated with nuclear functions.  |  Doerks, T., et al. 2002. Genome Res. 12: 47-56. PMID: 11779830
4. Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart.  |  Mao, R., et al. 2005. Genome Biol. 6: R107. PMID: 16420667
5. The discovery and mapping to chromosome 21 of the Alzheimer's amyloid gene: history revised.  |  Robakis, NK. 2006. J Alzheimers Dis. 10: 453-5. PMID: 17183160
6. Acute myeloid leukemia with the 8q22;21q22 translocation: secondary mutational events and alternative t(8;21) transcripts.  |  Peterson, LF., et al. 2007. Blood. 110: 799-805. PMID: 17412887
7. Classification of human chromosome 21 gene-expression variations in Down syndrome: impact on disease phenotypes.  |  Aït Yahya-Graison, E., et al. 2007. Am J Hum Genet. 81: 475-91. PMID: 17701894
8. Multi-Tissue Epigenetic and Gene Expression Analysis Combined With Epigenome Modulation Identifies RWDD2B as a Target of Osteoarthritis Susceptibility.  |  Parker, E., et al. 2021. Arthritis Rheumatol. 73: 100-109. PMID: 32755071
9. A transcriptome-wide association study provides new insights into the etiology of osteoarthritis.  |  Wang, W., et al. 2022. Ann Transl Med. 10: 1116. PMID: 36388797
10. The Causal Effects of Lifestyle Factors on Osteoarthritis: A Two-sample Mendelian Randomisation Study.  |  Ho, J., et al. 2025. Curr Rheumatol Rev.. PMID: 39819402
11. IsK and KvLQT1: mutation in either of the two subunits of the slow component of the delayed rectifier potassium channel can cause Jervell and Lange-Nielsen syndrome.  |  Tyson, J., et al. 1997. Hum Mol Genet. 6: 2179-85. PMID: 9328483

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-RWDD2B Antibody (D-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-RWDD2B Antibody (D-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

RWDD2B Antibody (D-4) Specifications

Alternate Product Name: RWDD2B

Product Clone Name: D-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 33-166

Epitope Target: RWDD2B

Epitope Species: human

Product Reactivity/Detection: RWDD2B

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for RWDD2B Antibody (D-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin