C1q-C Antibody (A-12): sc-365301
- C1q-C Antibody (A-12) is a mouse monoclonal IgG1 κ C1q-C antibody, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 101-155 of C1q-C of human origin
- C1q-C Antibody (A-12) is recommended for detection of precursor and mature C1q-C of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-C1q-C Antibody (A-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for C1q-C Antibody (A-12) for WB and IHC(P) applications. These reagents are now offered in bundles with C1q-C Antibody (A-12) (see ordering information below).
C1q-C Antibody (A-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects C1q-C protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). C1q-C (A-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. C1q-C protein is a crucial component of the classical complement pathway, which is essential for the immune response, as C1q-C protein facilitates the opsonization of pathogens and the clearance of immune complexes. Structurally, C1q is composed of nine subunits that form a unique bouquet-like structure, with six subunits existing as disulfide-linked dimers of chains A and B, while three subunits, designated C1q-A through C1q-C, are disulfide-linked dimers of chain C. This distinctive structure enables C1q to effectively bind to antibodies and pathogens, initiating the complement cascade. C1q interaction with receptors on effector cells can modulate immune responses, which may be antibody-dependent or independent, highlighting C1q′s role in both promoting and regulating inflammation. C1q is primarily produced by macrophages, and C1q expression can be influenced by anti-inflammatory drugs and cytokines, indicating C1q′s importance in maintaining immune homeostasis. Deficiencies in C1q-C, along with C1q-A and C1q-B, can lead to a rare genetic disorder characterized by lupus-like symptoms, underscoring C1q-C′s critical role in immune function and regulation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
C1q-C Antibody (A-12) References:
- C1q: structure, function, and receptors. | Kishore, U. and Reid, KB. 2000. Immunopharmacology. 49: 159-70. PMID: 10904115
- C1q regulatory region polymorphism down-regulating murine c1q protein levels with linkage to lupus nephritis. | Miura-Shimura, Y., et al. 2002. J Immunol. 169: 1334-9. PMID: 12133956
- Anti-inflammatory drugs modulate C1q secretion in human peritoneal macrophages in vitro. | Faust, D., et al. 2002. Biochem Pharmacol. 64: 457-62. PMID: 12147297
- In vitro modulation of C1q mRNA expression and secretion by interleukin-1, interleukin-6, and interferon-gamma in resident and stimulated murine peritoneal macrophages. | Faust, D. and Loos, M. 2002. Immunobiology. 206: 368-76. PMID: 12437068
- Complement factors in adult peripheral nerve: a potential role in energy metabolism. | Chrast, R., et al. 2004. Neurochem Int. 45: 353-9. PMID: 15145549
- Expression of the components and regulatory proteins of the classical pathway of complement in normal and diseased synovium. | Gulati, P., et al. 1994. Rheumatol Int. 14: 13-9. PMID: 7939135
- The mouse C1q genes are clustered on chromosome 4 and show conservation of gene organization. | Petry, F., et al. 1996. Immunogenetics. 43: 370-6. PMID: 8606057
- Platelet receptors for the complement component C1q: implications for hemostasis and thrombosis. | Peerschke, EI. and Ghebrehiwet, B. 1998. Immunobiology. 199: 239-49. PMID: 9777409
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
C1q-C Antibody (A-12) | sc-365301 | 200 µg/ml | $316.00 | |||
C1q-C Antibody (A-12): m-IgG Fc BP-HRP Bundle | sc-527350 | 200 µg Ab; 10 µg BP | $354.00 | |||
C1q-C Antibody (A-12): m-IgG1 BP-HRP Bundle | sc-532723 | 200 µg Ab; 20 µg BP | $354.00 | |||
C1q-C Antibody (A-12) AC | sc-365301 AC | 500 µg/ml, 25% agarose | $416.00 | |||
C1q-C Antibody (A-12) HRP | sc-365301 HRP | 200 µg/ml | $316.00 | |||
C1q-C Antibody (A-12) FITC | sc-365301 FITC | 200 µg/ml | $330.00 | |||
C1q-C Antibody (A-12) PE | sc-365301 PE | 200 µg/ml | $343.00 | |||
C1q-C Antibody (A-12) Alexa Fluor® 488 | sc-365301 AF488 | 200 µg/ml | $357.00 | |||
C1q-C Antibody (A-12) Alexa Fluor® 546 | sc-365301 AF546 | 200 µg/ml | $357.00 | |||
C1q-C Antibody (A-12) Alexa Fluor® 594 | sc-365301 AF594 | 200 µg/ml | $357.00 | |||
C1q-C Antibody (A-12) Alexa Fluor® 647 | sc-365301 AF647 | 200 µg/ml | $357.00 | |||
C1q-C Antibody (A-12) Alexa Fluor® 680 | sc-365301 AF680 | 200 µg/ml | $357.00 | |||
C1q-C Antibody (A-12) Alexa Fluor® 790 | sc-365301 AF790 | 200 µg/ml | $357.00 |