C1INH Antibody (B-11): sc-377062

C1INH Antibody (B-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects C1INH protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). C1INH (B-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. C1INH protein, also known as plasma protease C1 inhibitor, plays a critical role in regulating the complement and contact activation pathways, which are essential for maintaining homeostasis in the immune response. By inhibiting serine proteases such as C1r and C1s, C1INH prevents excessive inflammation and tissue damage, making C1INH vital for controlling the body′s response to injury and infection. Dysregulation of C1INH can lead to conditions such as hereditary angioedema, characterized by recurrent episodes of severe swelling, highlighting the importance of C1INH in both health and disease. Anti-C1INH antibody (B-11) is an invaluable tool for researchers studying the mechanisms of immune regulation and the pathophysiology of related disorders.

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C1INH Antibody (B-11) References:

1. N-linked glycosylation is required for c1 inhibitor-mediated protection from endotoxin shock in mice.  |  Liu, D., et al. 2004. Infect Immun. 72: 1946-55. PMID: 15039314
2. The pathophysiology of hereditary angioedema.  |  Davis, AE. 2005. Clin Immunol. 114: 3-9. PMID: 15596403
3. Adverse effects of danazol prophylaxis on the lipid profiles of patients with hereditary angioedema.  |  Széplaki, G., et al. 2005. J Allergy Clin Immunol. 115: 864-9. PMID: 15806011
4. Methylprednisolone affects inhibitors of the complement and the contact systems; functional and immunochemical studies on alpha 2-macroglobulin and C1 inhibitor.  |  Roeise, O., et al. 1989. Thromb Res. 56: 697-708. PMID: 2483762
5. The regulation of human factor XIIa by plasma proteinase inhibitors.  |  Pixley, RA., et al. 1985. J Biol Chem. 260: 1723-9. PMID: 2578463
6. The functional inhibition of activated C1 inhibitor in normal human serum causes spontaneous consumption of the complement components C2, C3, C4, and factor B.  |  Gronski, P., et al. 1986. Immunobiology. 171: 252-62. PMID: 3011651
7. Serum complexes between C1INH and C1INH autoantibodies for the diagnosis of acquired angioedema.  |  López-Lera, A., et al. 2019. Clin Exp Immunol. 198: 341-350. PMID: 31397881
8. Proteolysis and deglycosylation of human C1 inhibitor. Effect on functional properties.  |  Reboul, A., et al. 1987. Biochem J. 244: 117-21. PMID: 3311024
9. Targeting endometrial inflammation in intrauterine adhesion ameliorates endometrial fibrosis by priming MSCs to secrete C1INH.  |  Yao, S., et al. 2023. iScience. 26: 107201. PMID: 37456855
10. Real-life Experience of Subcutaneous Plasma Derived C1-Inhibitor as Long-term Prophylaxis in HAE-C1INH.  |  Entrala, A., et al. 2024. J Investig Allergol Clin Immunol. 34: 261-263. PMID: 38131209
11. Purification and characterization of two functionally distinct forms of C1 inhibitor from a patient with angioedema.  |  Curd, JG., et al. 1981. Clin Exp Immunol. 45: 261-70. PMID: 6976242
12. Inactivation of factor XIa in human plasma assessed by measuring factor XIa-protease inhibitor complexes: major role for C1-inhibitor.  |  Wuillemin, WA., et al. 1995. Blood. 85: 1517-26. PMID: 7534133

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-C1INH Antibody (B-11) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-C1INH Antibody (B-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

C1INH Antibody (B-11) Specifications

Alternate Product Name: C1INH

Product Clone Name: B-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 215-249

Epitope Target: C1INH

Epitope Species: human

Product Reactivity/Detection: C1INH

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for C1INH Antibody (B-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin