c-Kit Antibody (H-10): sc-393910

c-Kit Antibody (H-10) is a mouse monoclonal IgG2a kappa light chain antibody designed to detect c-Kit, a critical receptor tyrosine kinase involved in various cellular processes. c-Kit monoclonal antibody (H-10) targets an epitope mapping between amino acids 953-976 at the C-terminus of human c-Kit, ensuring precise binding and reliable detection in human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). c-Kit (H-10) antibody recognizes a protein characterized by five extracellular immunoglobulin-like domains responsible for ligand binding, a single transmembrane domain anchoring the receptor in the cell membrane, and an intracellular tyrosine kinase domain initiating downstream signaling upon activation. This structural configuration enables c-Kit′s role in mediating cell proliferation, differentiation, survival, and migration by interacting with stem cell factor (SCF). The precise arrangement of domains allows c-Kit to undergo dimerization and autophosphorylation, triggering signaling cascades vital for hematopoiesis, mast cell development, and stem cell maintenance. anti-c-Kit antibody (H-10) serves as an invaluable tool for studying c-Kit signaling in normal physiology and pathological conditions, as well as developing targeted therapeutic strategies for c-Kit-driven malignancies. Available in non-conjugated form and multiple conjugated variants, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and Alexa Fluor® conjugates, c-Kit (H-10) monoclonal antibody offers versatile applications for diverse research needs.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-c-Kit Antibody (H-10) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-c-Kit Antibody (H-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

c-Kit Antibody (H-10) Specifications

Alternate Product Name: c-Kit

Product Clone Name: H-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 953-976

Epitope Target: c-Kit

Epitope Species: human

Product Reactivity/Detection: c-Kit p145

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for c-Kit Antibody (H-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred c-Kit antibody is c-Kit Antibody (E-3): sc-365504.