c-Kit Antibody (Ab 81): sc-13508

c-Kit Antibody (Ab 81) is a mouse monoclonal IgG1 kappa light chain antibody engineered to detect the full-length human c-Kit protein in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). The c-Kit protein, also known as CD117, is a transmembrane receptor tyrosine kinase located on the cell surface, where c-Kit plays a pivotal role in regulating critical cellular processes including chemotaxis, proliferation, apoptosis, and adhesion by interacting with its ligand, stem cell factor (SCF). The cell surface localization of c-Kit is essential for its function in mediating signal transduction pathways that are vital for hematopoiesis, mast cell development, melanogenesis, and gametogenesis. This strategic positioning allows c-Kit to effectively respond to extracellular signals, thereby controlling essential biological functions and maintaining cellular homeostasis. Dysregulation or mutations in the c-Kit gene are closely associated with the development and progression of various cancers, such as gastrointestinal stromal tumors (GISTs) and certain types of leukemia, highlighting its significance as a target for both fundamental research and therapeutic interventions. c-Kit mouse monoclonal antibody (Ab 81) is raised against the full-length human c-Kit and is recommended for detection in human samples. Available in both conjugated and non-conjugated forms, c-Kit monoclonal antibody (Ab 81) is recommended for researchers investigating the mechanisms of c-Kit signaling, its role in disease pathology, and the development of targeted cancer therapies.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-c-Kit Antibody (Ab 81) has 56 citations in a variety of scientific publications.

Primary antibodies like Anti-c-Kit Antibody (Ab 81) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

c-Kit Antibody (Ab 81) Specifications

Alternate Product Name: c-Kit

Product Clone Name: Ab 81

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: c-Kit

Epitope Species: human

Product Reactivity/Detection: c-Kit

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 56 citations in various scientific publications

Available Conjugates/Forms for c-Kit Antibody (Ab 81): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred c-Kit antibody is c-Kit Antibody (E-3): sc-365504.