Date published: 2025-12-13

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c-IAP2 Antibody (Ac-71): sc-517317

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Datasheets
  • c-IAP2 Antibody (Ac-71) is a mouse monoclonal IgG1 κ c-IAP2 antibody, cited in 8 publications, provided at 50 µl ascites
  • raised against a recombinant protein corresponding to c-IAP2 of human origin
  • Endoplasmic Reticulum Staining
  • At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for c-IAP2 Antibody (Ac-71). This work is in progress.

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c-IAP2 Antibody (Ac-71) is a mouse monoclonal IgG1 kappa light chain antibody that detects c-IAP2 protein of human origin by western blotting (WB). anti-c-IAP2 antibody (Ac-71) is available as a non-conjugated format, providing a reliable tool for researchers studying apoptosis regulation. c-IAP2 protein, also known as BIRC3, plays a crucial role in inhibiting programmed cell death, which is vital for maintaining cellular homeostasis and preventing excessive cell loss in various physiological processes. c-IAP2 is primarily located in the cytoplasm and is involved in regulating apoptosis through interaction with key signaling pathways. Notably, c-IAP2 can bind to tumor necrosis factor receptor-associated factors (TRAFs), which are essential for mediating the effects of tumor necrosis factor (TNF) signaling. By modulating these interactions, c-IAP2 helps prevent TNF-induced apoptosis, thereby influencing immune responses and cell survival. Understanding c-IAP2 function and localization is important for elucidating its role in cancer biology and therapeutic resistance, making c-IAP2 (Ac-71) monoclonal antibody an invaluable resource for researchers investigating these critical pathways.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

c-IAP2 Antibody (Ac-71) References:

  1. [Expressions of c-IAP2 and Smac gene in leukemia and their clinical significance].  |  Wang, Y. and Zhou, JH. 2006. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 14: 217-20. PMID: 16638183
  2. Poly(I:C) induces intense expression of c-IAP2 and cooperates with an IAP inhibitor in induction of apoptosis in cancer cells.  |  Friboulet, L., et al. 2010. BMC Cancer. 10: 327. PMID: 20576118
  3. c-IAP1 and c-IAP2 redundancy differs between T and B cells.  |  Giardino Torchia, ML., et al. 2013. PLoS One. 8: e66161. PMID: 23799077
  4. Targeting c-IAP1, c-IAP2, and Bcl-2 Eliminates Senescent Glioblastoma Cells Following Temozolomide Treatment.  |  Schwarzenbach, C., et al. 2021. Cancers (Basel). 13: PMID: 34298797
  5. The baculovirus p35 protein inhibits Fas- and tumor necrosis factor-induced apoptosis.  |  Beidler, DR., et al. 1995. J Biol Chem. 270: 16526-8. PMID: 7542648
  6. Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35.  |  Bump, NJ., et al. 1995. Science. 269: 1885-8. PMID: 7569933
  7. Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein.  |  Xue, D. and Horvitz, HR. 1995. Nature. 377: 248-51. PMID: 7675111
  8. Expression of baculovirus P35 prevents cell death in Drosophila.  |  Hay, BA., et al. 1994. Development. 120: 2121-9. PMID: 7925015
  9. Control of programmed cell death by the baculovirus genes p35 and iap.  |  Clem, RJ. and Miller, LK. 1994. Mol Cell Biol. 14: 5212-22. PMID: 8035800
  10. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins.  |  Rothe, M., et al. 1995. Cell. 83: 1243-52. PMID: 8548810
  11. Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors.  |  Uren, AG., et al. 1996. Proc Natl Acad Sci U S A. 93: 4974-8. PMID: 8643514
  12. A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors.  |  Duckett, CS., et al. 1996. EMBO J. 15: 2685-94. PMID: 8654366

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

c-IAP2 Antibody (Ac-71)

sc-517317
50 µl ascites
$316.00