c-Fms/CSF-1R Antibody (3-4A4-E4): sc-57047

c-Fms/CSF-1R Antibody (3-4A4-E4) is a rat monoclonal IgG2b antibody that detects c-Fms/CSF-1R in mouse, rat, and human samples through immunoprecipitation (IP) and flow cytometry (FCM) applications. c-Fms/CSF-1R, also known as macrophage colony-stimulating factor receptor (M-CSFR), FIM2, or CD115, is a transmembrane tyrosine kinase receptor that plays a crucial role in the growth and differentiation of myeloid cells. c-Fms/CSF-1R is encoded by the c-Fms proto-oncogene and is predominantly expressed in mononuclear phagocytes, oocytes, decidual cells, trophoblastic cells, and certain myoblasts. c-Fms/CSF-1R mediates the functions of macrophage colony-stimulating factor (M-CSF), a glycoprotein essential for the proliferation and differentiation of mononuclear phagocytes, including osteoclasts. M-CSF is also a key player in the inflammatory response, regulating the release of proinflammatory cytokines from macrophages, which underscores c-Fms/CSF-1R′s importance in both immune response and tissue homeostasis. Anti-c-Fms/CSF-1R antibody (3-4A4-E4) enables researchers to gain valuable insights into the mechanisms of myeloid cell regulation and the broader implications of M-CSF signaling in various physiological and pathological contexts.

The preferred c-Fms/CSF-1R antibody is c-Fms/CSF-1R Antibody (B-8): sc-46662.