c-Fms/CSF-1R Antibody (0.N.179): sc-70453

c-Fms/CSF-1R Antibody (0.N.179) is a rat monoclonal IgG2b antibody that detects c-Fms/CSF-1R in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). c-Fms/CSF-1R, also known as macrophage colony-stimulating factor receptor (M-CSFR), FIM2, or CD115, is a transmembrane tyrosine kinase receptor that plays a crucial role in the growth and differentiation of myeloid cells. c-Fms/CSF-1R is encoded by the c-Fms proto-oncogene and is predominantly expressed in mononuclear phagocytes, oocytes, decidual cells, trophoblastic cells, and certain myoblasts. c-Fms/CSF-1R mediates the functions of macrophage colony-stimulating factor (M-CSF), a glycoprotein essential for the proliferation and differentiation of mononuclear phagocytes, including osteoclasts. M-CSF is also a key player in the inflammatory response, regulating the release of proinflammatory cytokines from macrophages, which underscores the importance of c-Fms/CSF-1R in both immune regulation and tissue homeostasis. Anti-c-Fms/CSF-1R antibody (0.N.179) enables researchers to gain valuable insights into the mechanisms of myeloid cell biology and the role of M-CSF in various physiological and pathological processes.

The preferred c-Fms/CSF-1R antibody is c-Fms/CSF-1R Antibody (B-8): sc-46662.