C/EBP ε Antibody (2154C4a): sc-130029
- C/EBP ε Antibody (2154C4a) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against a recombinant protein corresponding to an internal region of C/EBP ε of human origin
- recommended for detection of C/EBP ε of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for C/EBP ε Antibody (2154C4a). This work is in progress.
C/EBP ε Antibody (2154C4a) is a mouse monoclonal IgG1 antibody that detects C/EBP ε in human samples through western blotting (WB) and immunoprecipitation (IP) applications. C/EBP ε is a member of the CCAAT-enhancer binding protein family, which plays a crucial role in regulating gene expression across various tissues, including adipose tissue, liver, and immune cells. C/EBP ε is particularly important for its involvement in the differentiation of adipocytes and the regulation of metabolic processes, making C/EBP ε a key player in energy homeostasis and obesity-related research. Structurally, C/EBP ε features a bipartite DNA-binding domain that allows C/EBP ε to interact with specific cis-regulatory elements, facilitating function as a transcription factor. C/EBP ε′s ability to form homodimers and heterodimers with other C/EBP family members, such as C/EBP α and C/EBP β, enhances regulatory capacity and allows for complex gene expression patterns in response to various physiological signals. Anti-C/EBP ε antibody (2154C4a) is an essential tool for researchers investigating the roles of this transcription factor in metabolic diseases and cellular differentiation.
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C/EBP ε Antibody (2154C4a) References:
- C/EBP epsilon mediates myeloid differentiation and is regulated by the CCAAT displacement protein (CDP/cut). | Khanna-Gupta, A., et al. 2001. Proc Natl Acad Sci U S A. 98: 8000-5. PMID: 11438745
- Neutrophil specific granule deficiency and mutations in the gene encoding transcription factor C/EBP(epsilon). | Gombart, AF. and Koeffler, HP. 2002. Curr Opin Hematol. 9: 36-42. PMID: 11753076
- Macrophage functional maturation and cytokine production are impaired in C/EBP epsilon-deficient mice. | Tavor, S., et al. 2002. Blood. 99: 1794-801. PMID: 11861297
- Chromatin immunoprecipitation (ChIP) studies indicate a role for CCAAT enhancer binding proteins alpha and epsilon (C/EBP alpha and C/EBP epsilon) and CDP/cut in myeloid maturation-induced lactoferrin gene expression. | Khanna-Gupta, A., et al. 2003. Blood. 101: 3460-8. PMID: 12522000
- ATF4 differentially regulates transcriptional activation of myeloid-specific genes by C/EBPepsilon and C/EBPalpha. | Gombart, AF., et al. 2007. J Leukoc Biol. 81: 1535-47. PMID: 17347301
- Human C/EBP-epsilon activator and repressor isoforms differentially reprogram myeloid lineage commitment and differentiation. | Bedi, R., et al. 2009. Blood. 113: 317-27. PMID: 18832658
- miRNA-130a regulates C/EBP-ε expression during granulopoiesis. | Larsen, MT., et al. 2014. Blood. 123: 1079-89. PMID: 24398327
- Role of the Leucine Zipper Domain of CCAAT/ Enhancer Binding Protein-Epsilon (C/EBPε) in Neutrophil-Specific Granule Deficiency. | Wada, T. and Akagi, T. 2016. Crit Rev Immunol. 36: 349-358. PMID: 28322138
- C/EBPε and its acetylation in PMN enhance the tolerance to trauma. | Cheng, S., et al. 2025. Clin Exp Immunol. 219: PMID: 39028614
- A novel, myeloid transcription factor, C/EBP epsilon, is upregulated during granulocytic, but not monocytic, differentiation. | Morosetti, R., et al. 1997. Blood. 90: 2591-600. PMID: 9326225
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
C/EBP ε Antibody (2154C4a) | sc-130029 | 100 µg/ml | $339.00 |