c-Abl Antibody (24-11): sc-23

c-Abl Antibody (24-11) is a mouse monoclonal IgG1 antibody specifically engineered to recognize c-Abl protein, also known as ABL1, by targeting an epitope within the p120 C-terminus domain. c-Abl mouse monoclonal antibody (24-11) effectively detects both native c-Abl and the chimeric Bcr/Abl fusion proteins, which are pivotal in the pathology of chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL). c-Abl monoclonal antibody (24-11) exhibits broad species reactivity, being compatible with mouse, rat, and human samples, and is recommended for use in western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA) assays. c-Abl protein is a non-receptor tyrosine kinase that plays a crucial role in regulating various cellular processes, including differentiation, division, and adhesion. Located primarily in the cytoplasm and nucleus, c-Abl distribution is essential for function in signal transduction pathways and maintaining cellular homeostasis. Alterations in c-Abl localization and activity are significant in the development of certain leukemias, particularly through the formation of the Philadelphia chromosome, which results in the Bcr/c-Abl fusion protein with constitutive kinase activity. By targeting the specific p120 C-terminus region, c-Abl monoclonal antibody (24-11) ensures reliable detection of both wild-type and aberrant forms of c-Abl, facilitating important research and diagnostic applications in oncology and cell biology.

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c-Abl Antibody (24-11) References:

1. Three-dimensional solution structure of the src homology 2 domain of c-abl.  |  Overduin, M., et al. 1992. Cell. 70: 697-704. PMID: 1505033
2. Bcr encodes a GTPase-activating protein for p21rac.  |  Diekmann, D., et al. 1991. Nature. 351: 400-2. PMID: 1903516
3. c-Abl in neurodegenerative disease.  |  Schlatterer, SD., et al. 2011. J Mol Neurosci. 45: 445-52. PMID: 21728062
4. The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis.  |  Imamura, K., et al. 2017. Sci Transl Med. 9: PMID: 28539470
5. c-Abl Inhibitors as Disease-Modifying Therapies for Parkinson's Disease: Gaps and Opportunities.  |  Merchant, K. and Sullivan, J. 2022. Mov Disord. 37: 3-5. PMID: 35043450
6. Roles for c-Abl in postoperative neurodegeneration.  |  Feng, L., et al. 2022. Int J Med Sci. 19: 1753-1761. PMID: 36313229
7. c-Abl Regulates the Pathological Deposition of TDP-43 via Tyrosine 43 Phosphorylation.  |  Lee, S., et al. 2022. Cells. 11: PMID: 36552734
8. Evidence of a new chimeric bcr/c-abl mRNA in patients with chronic myelocytic leukemia and the Philadelphia chromosome.  |  Stam, K., et al. 1985. N Engl J Med. 313: 1429-33. PMID: 3864009
9. Lymphosarcoma: virus-induced thymic-independent disease in mice.  |  Abelson, HT. and Rabstein, LS. 1970. Cancer Res. 30: 2213-22. PMID: 4318922
10. Sequences of the A-MuLV protein needed for fibroblast and lymphoid cell transformation.  |  Prywes, R., et al. 1983. Cell. 34: 569-79. PMID: 6193890
11. An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity.  |  Konopka, JB., et al. 1984. Cell. 37: 1035-42. PMID: 6204766
12. A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia.  |  de Klein, A., et al. 1982. Nature. 300: 765-7. PMID: 6960256

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-c-Abl Antibody (24-11) has 203 citations in a variety of scientific publications.

Primary antibodies like Anti-c-Abl Antibody (24-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

c-Abl Antibody (24-11) Specifications

Alternate Product Name: ABL1

Product Clone Name: 24-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: c-Abl p120

Epitope Species:

Product Reactivity/Detection: c-Abl p120 and chimeric Bcr/Abl proteins in CML and ALL

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 203 citations in various scientific publications

Available Conjugates/Forms for c-Abl Antibody (24-11): N/A