Date published: 2026-4-4

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Butoxamine hydrochloride (CAS 5696-15-1)

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Alternate Names:
α-(1-[t-Butylamino]ethyl)-2,5-dimethoxybenzyl alcohol
Application:
Butoxamine hydrochloride is a β-2 selective β blocker
CAS Number:
5696-15-1
Purity:
≥96%
Molecular Weight:
303.82
Molecular Formula:
C15H25NO3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Butoxamine hydrochloride is a selective β-2 adrenergic antagonist that exhibits β-2 selectivity. It is utilized in animal and tissue experiments to identify and characterize β-2 adrenergic receptors. This compound is the hydrochloride salt form of butoxamine, which is known for its specificity towards β-2 receptors. By focusing on β-2 receptors, butoxamine hydrochloride enables researchers to gain insights into the function and properties of these receptors in various experimental applications.


Butoxamine hydrochloride (CAS 5696-15-1) References

  1. Atenolol or butoxamine injection at the lateral septum doesn't inhibit male sexual behavior in rats.  |  Gulia, KK., et al. 2005. Indian J Physiol Pharmacol. 49: 103-7. PMID: 15881867
  2. Pharmacological characterization of isoproterenol-treated medaka fish.  |  Kawasaki, T., et al. 2008. Pharmacol Res. 58: 348-55. PMID: 18951980
  3. Immunomodulation of neutrophil–endothelial interaction by inotropes.  |  Trabold, B., et al. 2010. Injury. 41: 1079-83. PMID: 20566195
  4. β2-adrenergic receptor antagonist butoxamine partly abolishes the protection of 100% oxygen treatment against zymosan-induced generalized inflammation in mice.  |  Pei, Y., et al. 2011. Shock. 36: 272-8. PMID: 21617579
  5. Acute hypoglycemia causes depressive-like behaviors in mice.  |  Park, MJ., et al. 2012. Metabolism. 61: 229-36. PMID: 21820138
  6. Dose effects of butoxamine, a selective β2-adrenoceptor antagonist, on bone metabolism in spontaneously hypertensive rat.  |  Arai, M., et al. 2013. Eur J Pharmacol. 701: 7-13. PMID: 23321373
  7. Selective β2-adrenergic Antagonist Butoxamine Reduces Orthodontic Tooth Movement.  |  Sato, T., et al. 2014. J Dent Res. 93: 807-12. PMID: 24868013
  8. Altered uterine contractility in response to β-adrenoceptor agonists in ovarian cancer.  |  Modzelewska, B., et al. 2017. J Physiol Sci. 67: 711-722. PMID: 27838886
  9. Metoprolol decreases retention of fear memory and facilitates long-term depression in lateral amygdala.  |  Luo, Y., et al. 2020. Behav Pharmacol. 31: 535-543. PMID: 31860562
  10. Suppression of tooth movement-induced sclerostin expression using β-adrenergic receptor blockers.  |  Uchibori, S., et al. 2020. Oral Dis. 26: 621-629. PMID: 31943597
  11. Myometrial Responses to Beta-Adrenoceptor Antagonists in Gynecological Malignancies.  |  Modzelewska, B., et al. 2021. Gynecol Obstet Invest. 86: 162-169. PMID: 33640886
  12. Effects of a β2-adrenergic receptor blocker on experimental periodontitis in spontaneously hypertensive rats.  |  Takeguchi, A., et al. 2021. Life Sci. 277: 119593. PMID: 33979569
  13. A ganglionic blocker and adrenoceptor ligands modify clozapine-induced insulin resistance.  |  Yuen, JWY., et al. 2021. Psychoneuroendocrinology. 129: 105257. PMID: 34023734
  14. Selective β2-Adrenoceptor Blockade Rescues Mandibular Growth Retardation in Adolescent Rats Exposed to Chronic Intermittent Hypoxia.  |  Hong, H., et al. 2021. Front Physiol. 12: 676270. PMID: 34220541
  15. Noradrenaline and seizures: a perspective on the role of adrenergic receptors in limbic seizures.  |  Biagioni, F., et al. 2022. Curr Neuropharmacol.. PMID: 35339181

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Butoxamine hydrochloride, 50 mg

sc-234233
50 mg
$206.00

Butoxamine hydrochloride, 500 mg

sc-234233A
500 mg
$981.00

Butoxamine hydrochloride, 1 g

sc-234233B
1 g
$1414.00

Butoxamine hydrochloride, 10 g

sc-234233C
10 g
$12858.00