BUP-1 Antibody (G-9): sc-390541

BUP-1 Antibody (G-9) is a mouse monoclonal IgG1 antibody that detects BUP-1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). BUP-1, also known as β-ureidopropionase or N-carbamyl-β-alanine amidohydrolase, plays a crucial role in the catabolism of pyrimidines, specifically catalyzing the hydrolysis of N-carbamyl-β-aminoisobutyric acid to produce β-aminoisobutyric acid, ammonia, and carbon dioxide. This enzymatic activity is vital for the proper degradation of thymine and uracil, and any deficiency in BUP-1 can lead to the accumulation of toxic metabolites such as N-carbamyl-β-aminoisobutyric acid and N-carbamyl-β-alanine in biological fluids, which may result in neurological disturbances. The localization of BUP-1 in the cytoplasm of liver and kidney cells underscores BUP-1′s importance in metabolic processes, as these organs are central to the regulation of nitrogenous waste and amino acid metabolism. BUP-1 monoclonal antibody (G-9) is an essential tool for researchers studying metabolic disorders and the biochemical pathways involving pyrimidine degradation.

The preferred BUP-1 antibody is BUP-1 Antibody (F-11): sc-374066.