brevican Antibody (2): sc-135849

Brevican Antibody (2) is a mouse monoclonal IgG1 kappa light chain antibody that detects brevican protein of mouse, rat, and canine origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-brevican antibody (2) is available as the non-conjugated format, providing researchers with a reliable tool for studying this important brain proteoglycan. Brevican plays a crucial role in the central nervous system, where brevican is primarily located in the extracellular matrix of the brain, contributing to the structural integrity and organization of neural tissues. This localization is vital for maintaining proper functioning of synapses and facilitating cell signaling, which are essential for cognitive processes and overall brain health. As a member of the aggrecan/versican/neurocan family, brevican is characterized by a unique structure, which includes a core protein that can undergo proteolytic cleavage, resulting in various fragments that may have distinct biological functions. Brevican is often found in a form that lacks glycosaminoglycan chains, highlighting brevican′s dual role as both a structural component and a signaling molecule in the brain. The gene encoding brevican is located on mouse chromosome 3, providing a genetic basis for study in various models. With specific reactivity and versatile applications, anti-brevican antibody (2) is an invaluable resource for researchers investigating the complexities of brain proteoglycans and their implications in neurological health and disease.

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brevican Antibody (2) References:

1. Fibulin-1 is a ligand for the C-type lectin domains of aggrecan and versican.  |  Aspberg, A., et al. 1999. J Biol Chem. 274: 20444-9. PMID: 10400671
2. Brevican-containing perineuronal nets of extracellular matrix in dissociated hippocampal primary cultures.  |  John, N., et al. 2006. Mol Cell Neurosci. 31: 774-84. PMID: 16503162
3. Brevican and phosphacan expression and localization following transient middle cerebral artery occlusion in the rat.  |  Haddock, G., et al. 2007. Biochem Soc Trans. 35: 692-4. PMID: 17635124
4. Brevican distinctively assembles extracellular components at the large diameter nodes of Ranvier in the CNS.  |  Bekku, Y., et al. 2009. J Neurochem. 108: 1266-76. PMID: 19141078
5. Brevican knockdown reduces late-stage glioma tumor aggressiveness.  |  Dwyer, CA., et al. 2014. J Neurooncol. 120: 63-72. PMID: 25052349
6. The extracellular matrix molecule brevican is an integral component of the machinery mediating fast synaptic transmission at the calyx of Held.  |  Blosa, M., et al. 2015. J Physiol. 593: 4341-60. PMID: 26223835
7. Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican.  |  Favuzzi, E., et al. 2017. Neuron. 95: 639-655.e10. PMID: 28712654
8. The Perineuronal Net Protein Brevican Acts in Nucleus Accumbens Parvalbumin-Expressing Interneurons of Adult Mice to Regulate Excitatory Synaptic Inputs and Motivated Behaviors.  |  Hazlett, MF., et al. 2024. Biol Psychiatry. 96: 694-707. PMID: 38346480
9. cDNA cloning and the identification of an aggrecanase-like cleavage site in rat brevican.  |  Yamada, H., et al. 1995. Biochem Biophys Res Commun. 216: 957-63. PMID: 7488217
10. Molecular cloning of brevican, a novel brain proteoglycan of the aggrecan/versican family.  |  Yamada, H., et al. 1994. J Biol Chem. 269: 10119-26. PMID: 8144512
11. Sequence and chromosomal localization of the mouse brevican gene.  |  Rauch, U., et al. 1997. Genomics. 44: 15-21. PMID: 9286696
12. Expression of a cleaved brain-specific extracellular matrix protein mediates glioma cell invasion In vivo.  |  Zhang, H., et al. 1998. J Neurosci. 18: 2370-6. PMID: 9502798

The preferred aggrecan/brevican antibody is aggrecan/brevican Antibody (D-4): sc-166951.