BRD2 Antibody (D-2): sc-514102
- BRD2 Antibody (D-2) is a mouse monoclonal IgM κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 217-236 within an internal region of BRD2 of human origin
- recommended for detection of BRD2 of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for BRD2 Antibody (D-2). This work is in progress.
BRD2 Antibody (D-2) is a mouse monoclonal IgM antibody that detects BRD2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BRD2, also known as RING3 protein, plays a crucial role as a mitogen-activated nuclear protein, which is essential for regulating gene expression in response to cellular signals. BRD2′s gene is located in the human major histocompatibility complex (MHC) class II region, linking BRD2 to HLA-associated diseases and highlighting BRD2′s importance in immune response and potential implications in autoimmune disorders. BRD2′s ability to interact with various transcription factors and chromatin remodeling complexes underscores BRD2′s significance in cellular processes such as proliferation and differentiation. Furthermore, BRD2 is part of a larger family of bromodomain-containing proteins, which are known for their role in recognizing acetylated lysines on histones, thus influencing chromatin structure and gene accessibility. Anti-BRD2 antibody (D-2) is a valuable tool for researchers investigating the molecular mechanisms underlying these processes and their implications in health and disease.
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BRD2 Antibody (D-2) References:
- Brd2 inhibits adipogenesis via the ERK1/2 signaling pathway in 3T3-L1 adipocytes. | Zang, K., et al. 2013. PLoS One. 8: e78536. PMID: 24194944
- The double bromodomain protein Brd2 promotes B cell expansion and mitogenesis. | Belkina, AC., et al. 2014. J Leukoc Biol. 95: 451-60. PMID: 24319289
- Sex-specific behavioral traits in the Brd2 mouse model of juvenile myoclonic epilepsy. | Chachua, T., et al. 2014. Genes Brain Behav. 13: 702-12. PMID: 25130458
- Pleiotrophin fights Brd2 for neuronal differentiation. | Garcia-Gutierrez, P. and Garcia-Dominguez, M. 2015. Neural Regen Res. 10: 544-6. PMID: 26170807
- JQ1 affects BRD2-dependent and independent transcription regulation without disrupting H4-hyperacetylated chromatin states. | Handoko, L., et al. 2018. Epigenetics. 13: 410-431. PMID: 30080437
- HDAC11 suppresses the thermogenic program of adipose tissue via BRD2. | Bagchi, RA., et al. 2018. JCI Insight. 3: PMID: 30089714
- CRISPR Screen Reveals BRD2/4 Molecular Glue-like Degrader via Recruitment of DCAF16. | Shergalis, AG., et al. 2023. ACS Chem Biol. 18: 331-339. PMID: 36656921
- Glioblastoma Mesenchymal Transition and Invasion are Dependent on a NF-κB/BRD2 Chromatin Complex. | Vadla, R., et al. 2023. bioRxiv.. PMID: 37461511
- BRD2 and BRD3 genes independently evolved RNA structures to control unproductive splicing. | Petrova, M., et al. 2024. NAR Genom Bioinform. 6: lqad113. PMID: 38226395
- Novel BRD2::NUTM1 Fusion in NUT Carcinoma With Exceptional Response to Chemotherapy: A Case Report. | Wu, SJ., et al. 2024. JTO Clin Res Rep. 5: 100625. PMID: 38287941
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BRD2 Antibody (D-2) | sc-514102 | 200 µg/ml | $316.00 | |||
BRD2 (D-2) Neutralizing Peptide | sc-514102 P | 100 µg/0.5 ml | $68.00 |