Dieser polyklonale Antikörper wird nicht mehr hergestellt. Wir empfehlen Ihnen unseren BRCA2 (3D12) monoklonalen Antikörper (Beispielsdaten werden angezeigt).
BRCA2 Antikörper (C-19): sc-1817
- BRCA2 Antikörper C-19 ist ein polyklonales IgG aus der Ziege in einer Menge von 200 µg/ml
- das Epitop liegt in der Nähe des C-terminus von BRCA2 aus der Spezies human
- Nicht länger erhältlicher polyklonaler Antikörper
Direktverknüpfungen
Beschreibung
In 1990, a breast cancer susceptibility gene designated BRCA1 was localized to chromosome 17q. Mutations within this gene are believed to account for approximately 45% of families with high incidence of breast cancer and at least 80% of families with increased incidence of both early-onset breast cancer and ovarian cancer. A second breast cancer susceptibility gene, BRCA2 (breast cancer 2, early onset), located on chromosome 13q12.3, also confers a high incidence of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer. Both BRCA1 and BRCA2 play a role in the maintainance of genome stability, particularly in the homologous recombination pathway for double-strand DNA repair. BRCA2 is regarded as a tumor suppressor gene; tumors with BRCA2 mutations exhibit loss of heterozygosity (LOH) of the wildtype allele. The protein encoded by the BRCA2 gene contains multiple copies of a 70 amino acid motif called the BRC motif. These motifs effect binding to the Rad51 recombinase, which operates in DNA repair.
Bestellinformation
BRCA2 (3D12): sc-293185 [ Empfohlener monoklonaler Ersatz für BRCA2 (C-19) ]
| Produkt | Katalog # | EINHEIT | Preis | ANZAHL | Favoriten | |
BRCA2 Antikörper (3D12) | sc-293185 | 100 µg/ml | $316.00 | |||
BRCA2 (3D12): m-IgG3 BP-HRP Bundle | sc-550414 | 100 µg Ab; 40 µg BP | $354.00 |