BRCA2 Antibody (184H2N): sc-517636
- BRCA2 Antibody (184H2N) is a mouse monoclonal IgG1 κ provided at 100 µg/ml
- raised against recombinant BRCA2 of human origin
- recommended for detection of BRCA2 of human origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for BRCA2 Antibody (184H2N). This work is in progress.
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BRCA2 Antibody (184H2N) is a mouse monoclonal IgG1 antibody that detects BRCA2 in human samples through western blotting (WB). BRCA2 is a crucial tumor suppressor protein that plays a significant role in maintaining genomic stability, particularly through involvement in the homologous recombination pathway for double-strand DNA repair. BRCA2 is located primarily in the nucleus, where BRCA2 facilitates the repair of DNA breaks, thereby preventing the accumulation of mutations that can lead to cancer. Nuclear localization of BRCA2 ensures ready availability to interact with other key players in the DNA repair process, such as Rad51. Mutations in the BRCA2 gene can lead to a loss of function, resulting in an increased risk of breast and ovarian cancers due to the inability to effectively repair DNA damage. BRCA2 contains multiple copies of a 70 amino acid motif known as the BRC motif, which is essential for interaction with Rad51, underscoring the intricate relationship between protein structure and function in cancer biology. Anti-BRCA2 antibody (184H2N) is an invaluable tool for researchers studying molecular mechanisms underlying breast cancer susceptibility and broader implications of DNA repair pathways in oncogenesis.
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BRCA2 Antibody (184H2N) References:
- Cycling with BRCA2 from DNA repair to mitosis. | Lee, H. 2014. Exp Cell Res. 329: 78-84. PMID: 25447315
- Pancreatic ductal adenocarcinoma in BRCA2 mutation carriers. | de Mestier, L., et al. 2016. Endocr Relat Cancer. 23: T57-67. PMID: 27511924
- The influence of BRCA2 mutation on localized prostate cancer. | Taylor, RA., et al. 2019. Nat Rev Urol. 16: 281-290. PMID: 30808988
- The Post-Synaptic Function of Brca2. | Wang, CX., et al. 2019. Sci Rep. 9: 4554. PMID: 30872704
- The phospho-dependent role of BRCA2 on the maintenance of chromosome integrity. | Ehlén, Å., et al. 2021. Cell Cycle. 20: 731-741. PMID: 33691600
- BRCA1 and BRCA2 Tumor Suppressor Function in Meiosis. | Li, Q. and Engebrecht, J. 2021. Front Cell Dev Biol. 9: 668309. PMID: 33996823
- BRCA2 Promotes Spontaneous Homologous Recombination In Vivo. | Brown, AD., et al. 2021. Cancers (Basel). 13: PMID: 34359565
- BRCA2 represses the transcriptional activity of pS2 by E2-ERα. | Fukuda, M., et al. 2022. Biochem Biophys Res Commun. 588: 75-82. PMID: 34952473
- Alterations in BRCA2 as Determinants of Therapy Response in Prostate Cancer. | Hofstad, M., et al. 2022. Crit Rev Oncog. 27: 81-96. PMID: 35993980
- Cell origin of BRCA2-mutant breast cancer. | Xu, J. and Liu, S. 2024. Nat Cell Biol. 26: 43-44. PMID: 38216736
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BRCA2 Antibody (184H2N) | sc-517636 | 100 µg/ml | $322.00 |