BRCA2 Antibody (1643CT739.91.87): sc-517316

BRCA2 Antibody (1643CT739.91.87) is a mouse monoclonal IgG1 antibody that detects BRCA2 in human samples by western blotting (WB). BRCA2 is a crucial tumor suppressor protein that plays a significant role in maintaining genome stability, particularly through involvement in the homologous recombination pathway for double-strand DNA repair. BRCA2 is primarily located in the nucleus, where anti-BRCA2 antibody (1643CT739.91.87) can detect DNA break repair activity, preventing genomic instability that leads to cancer. Mutations in the BRCA2 gene are associated with a high incidence of breast cancer and are particularly notable for their role in familial breast and ovarian cancer syndromes. BRCA2 contains multiple copies of a 70 amino acid motif known as the BRC motif, which is essential for interaction with the Rad51 recombinase, a key player in the DNA repair process. Through binding to Rad51, BRCA2 helps ensure accurate repair of DNA, thus preventing the accumulation of mutations that can lead to tumorigenesis. BRCA2′s ability to maintain genomic integrity underscores its importance in cancer biology and highlights BRCA2 (1643CT739.91.87) antibody′s relevance in research focused on understanding breast cancer mechanisms and developing targeted therapies.

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BRCA2 Antibody (1643CT739.91.87) References:

1. BRCA2 and homologous recombination.  |  Orelli, BJ. and Bishop, DK. 2001. Breast Cancer Res. 3: 294-8. PMID: 11597317
2. Molding BRCA2 function through its interacting partners.  |  Martinez, JS., et al. 2015. Cell Cycle. 14: 3389-95. PMID: 26566862
3. BRCA2 functions: from DNA repair to replication fork stabilization.  |  Fradet-Turcotte, A., et al. 2016. Endocr Relat Cancer. 23: T1-T17. PMID: 27530658
4. BRCA2 and Other DDR Genes in Prostate Cancer.  |  Nombela, P., et al. 2019. Cancers (Basel). 11: PMID: 30871108
5. The interplay between miR-1245a and BRCA2 in colorectal cancer.  |  Scorilas, A., et al. 2020. Ann Transl Med. 8: 1043. PMID: 33145262
6. Discovery of BRCA1/BRCA2 founder variants by haplotype analysis.  |  Kwon, WK., et al. 2022. Cancer Genet. 266-267: 19-27. PMID: 35671604
7. BRCA2 chaperones RAD51 to single molecules of RPA-coated ssDNA.  |  Bell, JC., et al. 2023. Proc Natl Acad Sci U S A. 120: e2221971120. PMID: 36976771
8. Structural basis for stabilisation of the RAD51 nucleoprotein filament by BRCA2.  |  Appleby, R., et al. 2023. Nat Commun. 14: 7003. PMID: 37919288
9. The BRCA2 R2645G variant increases DNA binding and induces hyper-recombination.  |  Alvaro-Aranda, L., et al. 2024. Nucleic Acids Res. 52: 6964-6976. PMID: 38142462
10. A glycolytic metabolite that drives BRCA2 haploinsufficiency.  |  Jiang, P. 2024. Cell. 187: 2124-2126. PMID: 38670069

The preferred BRCA2 antibody is BRCA2 Antibody (D-8): sc-518154.