bradykinin B1 R Antibody (3A2): sc-293196

Bradykinin B1 R Antibody (3A2) is a mouse monoclonal IgG2a kappa light chain antibody that detects bradykinin B1 receptor of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-bradykinin B1 R antibody (3A2) is available as a non-conjugated format. Bradykinin B1 receptor plays a crucial role in the body′s response to inflammation and pain, primarily mediating the effects of bradykinin, a peptide generated during tissue injury and inflammation. Bradykinin B1 R (3A2) antibody helps study this receptor′s involvement in cardiovascular homeostasis. Bradykinin B1 R expresses at low levels under normal physiological conditions but upregulates in response to inflammatory stimuli, such as cytokines and bacterial lipopolysaccharides. This inducible expression makes bradykinin B1 R a significant target for therapeutic interventions aimed at treating inflammatory diseases and cardiovascular conditions. Anti-bradykinin B1 R antibody (3A2) enables valuable insights into pain and inflammation mechanisms, supporting research into potential drug development pathways targeting this receptor.

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bradykinin B1 R Antibody (3A2) References:

1. Bradykinin B1 receptor expression and function on T lymphocytes in active multiple sclerosis.  |  Prat, A., et al. 1999. Neurology. 53: 2087-92. PMID: 10599786
2. Regulation of the human bradykinin B2 receptor expressed in sf21 insect cells: a possible role for tyrosine kinases.  |  Reyes-Cruz, G., et al. 2000. J Cell Biochem. 76: 658-73. PMID: 10653985
3. Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptors.  |  Pesquero, JB., et al. 2000. Proc Natl Acad Sci U S A. 97: 8140-5. PMID: 10859349
4. Activation of bradykinin B1 receptor by ACE inhibitors.  |  Ignjatovic, T., et al. 2002. Int Immunopharmacol. 2: 1787-93. PMID: 12489793
5. Bradykinin B1 receptor-mediated vasodilation is impaired in myometrial arteries from women with pre-eclampsia.  |  Moyes, AJ., et al. 2014. Hypertens Pregnancy. 33: 177-90. PMID: 24304135
6. Bradykinin B1 receptor contributes to interleukin-8 production and glioblastoma migration through interaction of STAT3 and SP-1.  |  Liu, YS., et al. 2019. Neuropharmacology. 144: 143-154. PMID: 30366000
7. Bradykinin B1 Receptor Affects Tumor-Associated Macrophage Activity and Glioblastoma Progression.  |  Shen, CK., et al. 2023. Antioxidants (Basel). 12: PMID: 37627528
8. Targeted disruption of a B2 bradykinin receptor gene in mice eliminates bradykinin action in smooth muscle and neurons.  |  Borkowski, JA., et al. 1995. J Biol Chem. 270: 13706-10. PMID: 7775424
9. Kinins and respiratory tract diseases.  |  Trifilieff, A., et al. 1993. Eur Respir J. 6: 576-87. PMID: 8387934
10. Effects of the bradykinin B1 receptor antagonist des-Arg9[Leu8]bradykinin and genetic disruption of the B2 receptor on nociception in rats and mice.  |  Rupniak, NM., et al. 1997. Pain. 71: 89-97. PMID: 9200178
11. Transcription factor nuclear factor kappaB regulates the inducible expression of the human B1 receptor gene in inflammation.  |  Ni, A., et al. 1998. J Biol Chem. 273: 2784-91. PMID: 9446586
12. Renal bradykinin receptors: localisation, transduction pathways and molecular basis for a possible pathological role (review).  |  Schanstra, JP., et al. 1999. Int J Mol Med. 3: 185-91. PMID: 9917528

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-bradykinin B1 R Antibody (3A2) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-bradykinin B1 R Antibody (3A2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

bradykinin B1 R Antibody (3A2) Specifications

Alternate Product Name: BDKRB1

Product Clone Name: 3A2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-353

Epitope Target: bradykinin B1 R

Epitope Species: human

Product Reactivity/Detection: bradykinin B1 R

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for bradykinin B1 R Antibody (3A2): N/A

The preferred bradykinin B1 R antibody is bradykinin B1 R Antibody (F-11): sc-518136.