bpV(phen) (CAS 171202-16-7)
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bpV(phen), or potassium bisperoxo (1,10-phenanthroline) oxovanadate, is a peroxovanadium (pV) small molecule with insulin-mimetic properties. bpV(phen) and other pV compounds were demonstrated to activate insulin receptor kinase in hepatocytes and to inhibit the dephosphorylation of autophosphorylated insulin receptors, correlated to significant decreases of circulating insulin and plasma glucose levels. Inhibition of an endosomally-located protein phosphotyrosine phosphatase by bpV(phen) produces this blockade of insulin receptor dephosphorylation. bpV(phen) is also described to activate a signal pathway which abrogates dexamethasone/glucagon-induced increase of IGFBP-1 (insulin-like growth factor binding protein-1) mRNA, and this effect is suggested to be mediated through MAP kinase activity stimulated by bpV(phen) inhibition of tyrosine phosphatases involved in MAP kinase regulation.
bpV(phen) (CAS 171202-16-7) References
- Activation of MAPK by potassium bisperoxo(1,10-phenanthroline)oxovanadate (V). | Cerovac, Z., et al. 1999. Neurochem Int. 34: 337-44. PMID: 10372920
- Molecular mechanisms involved in the antiproliferative action of protein tyrosine phosphatase inhibitor potassium bisperoxo(1,10-phenanthroline)oxovanadate. | Ban, J., et al. 2000. Life Sci. 68: 165-75. PMID: 11191635
- Effects of bpV(pic) and bpV(phen) on H9c2 cardiomyoblasts during both hypoxia/reoxygenation and H2O2-induced injuries. | Tian, Y., et al. 2012. Mol Med Rep. 5: 852-8. PMID: 22200881
- Regulation of rod photoreceptor differentiation by STAT3 is controlled by a tyrosine phosphatase. | Pinzon-Guzman, C., et al. 2015. J Mol Neurosci. 55: 152-159. PMID: 25108518
- Potassium Bisperoxo(1,10-phenanthroline)oxovanadate (bpV(phen)) Induces Apoptosis and Pyroptosis and Disrupts the P62-HDAC6 Protein Interaction to Suppress the Acetylated Microtubule-dependent Degradation of Autophagosomes. | Chen, Q., et al. 2015. J Biol Chem. 290: 26051-8. PMID: 26363065
- Ectophosphatase activity in the early-diverging fungus Blastocladiella emersonii: Biochemical characterization and possible role on cell differentiation. | Gomes-Vieira, AL., et al. 2018. Fungal Genet Biol. 117: 43-53. PMID: 30030178
- Potassium bisperoxo (1,10-phenanthroline) oxovanadate suppresses proliferation of hippocampal neuronal cell lines by increasing DNA methyltransferases. | Tian, XL., et al. 2019. Neural Regen Res. 14: 826-833. PMID: 30688268
- PTEN-mediated mitophagy and APE1 overexpression protects against cardiac hypoxia/reoxygenation injury. | Tang, W., et al. 2019. In Vitro Cell Dev Biol Anim. 55: 741-748. PMID: 31432320
- Hypoglycemic effects of peroxovanadium compounds in Sprague-Dawley and diabetic BB rats. | Yale, JF., et al. 1995. Diabetes. 44: 1274-9. PMID: 7589823
- In vivo insulin mimetic effects of pV compounds: role for tissue targeting in determining potency. | Bevan, AP., et al. 1995. Am J Physiol. 268: E60-6. PMID: 7840184
- Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics. | Posner, BI., et al. 1994. J Biol Chem. 269: 4596-604. PMID: 8308031
- A role for tyrosine phosphorylation in both activation and inhibition of the insulin receptor tyrosine kinase in vivo. | Drake, PG., et al. 1996. Endocrinology. 137: 4960-8. PMID: 8895369
- Phosphatidylinositol 3'-kinase and p70s6k are required for insulin but not bisperoxovanadium 1,10-phenanthroline (bpV(phen)) inhibition of insulin-like growth factor binding protein gene expression. Evidence for MEK-independent activation of mitogen-activated protein kinase by bpV(phen). | Band, CJ. and Posner, BI. 1997. J Biol Chem. 272: 138-45. PMID: 8995239
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
bpV(phen), 5 mg | sc-221378 | 5 mg | $96.00 | |||
bpV(phen), 25 mg | sc-221378A | 25 mg | $286.00 |