Bordetella pertussis toxin subunit S1 Antibody (63.1G9): sc-57639

Bordetella pertussis toxin subunit S1 Antibody (63.1G9) is a mouse monoclonal IgG1 antibody that detects Bordetella pertussis toxin subunit S1 of Bordetella pertussis origin by western blotting (WB). Bordetella pertussis toxin subunit S1 (63.1G9) antibody is available in a non-conjugated form, specifically designed for researchers studying the pathogenic mechanisms of Bordetella pertussis, the Gram-negative bacterium responsible for whooping cough, a highly contagious respiratory illness. The S1 subunit of the pertussis toxin plays a crucial role in toxin function by facilitating ADP-ribosylation of the Gi protein, which disrupts normal cellular signaling pathways. This modification leads to an increase in cyclic AMP levels, resulting in excessive mucus production and impaired immune responses, which are key factors in disease progression. Understanding the structure and function of the S1 subunit is vital for developing targeted therapies and vaccines against pertussis, as S1 is a major virulence factor that contributes to the bacterium′s ability to evade host defenses. Using anti-Bordetella pertussis toxin subunit S1 antibody (63.1G9) in research can provide valuable insights into the molecular interactions and pathogenicity of Bordetella pertussis, ultimately aiding in the fight against this significant public health concern.

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Bordetella pertussis toxin subunit S1 Antibody (63.1G9) References:

1. Comparison of the Bordetella pertussis and Bordetella parapertussis isolates circulating in Saint Petersburg between 1998 and 2000 with Russian vaccine strains.  |  Kourova, N., et al. 2003. J Clin Microbiol. 41: 3706-11. PMID: 12904379
2. Bordetella pertussis acquires resistance to complement-mediated killing in vivo.  |  Pishko, EJ., et al. 2003. Infect Immun. 71: 4936-42. PMID: 12933835
3. Humoral immunity against Bordetella pertussis: antibodies or B cells?  |  Rodriguez, ME. and van der Pol, WL. 2003. Infect Immun. 71: 6686; author reply 6686. PMID: 14573698
4. Comparison of real-time PCR and pyrosequencing for typing Bordetella pertussis toxin subunit 1 variants.  |  Storm, M., et al. 2006. J Microbiol Methods. 65: 153-8. PMID: 16095736
5. Induction of humoral immunity in response to immunization with recombinant Mycobacterium bovis BCG expressing the S1 subunit of Bordetella pertussis toxin.  |  Medeiros, MA., et al. 2005. Can J Microbiol. 51: 1015-20. PMID: 16462859
6. Bordetella pertussis respiratory infection following hematopoietic stem cell transplantation: time for universal vaccination?  |  Florax, A., et al. 2006. Bone Marrow Transplant. 38: 639-40. PMID: 16964268
7. Description of a hybridoma bank towards Bordetella pertussis toxin and surface antigens.  |  Poolman, JT., et al. 1990. Microb Pathog. 8: 377-82. PMID: 1980000
8. Cloning and sequencing of the pertussis toxin genes: operon structure and gene duplication.  |  Nicosia, A., et al. 1986. Proc Natl Acad Sci U S A. 83: 4631-5. PMID: 2873570
9. Multiple species and isoforms of Bordetella pertussis toxin substrates.  |  Brabet, P., et al. 1988. Biochem Biophys Res Commun. 152: 1185-92. PMID: 3132153

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Bordetella pertussis toxin subunit S1 Antibody (63.1G9) has 5 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Bordetella pertussis toxin subunit S1 Antibody (63.1G9) Specifications

Alternate Product Name: Bordetella pertussis toxin subunit S1

Product Clone Name: 63.1G9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Bordetella pertussis toxin subunit S1

Epitope Species: Bordetella pertussis

Product Reactivity/Detection: the S1 subunit and the intact toxin

Species Reactivity/Detection: Bordetella pertussis

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB

Vialing Information: Each vial contains 50 µg IgG₁ in 500 µl of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for Bordetella pertussis toxin subunit S1 Antibody (63.1G9): N/A