bomapin Antibody (B-3): sc-514795
- bomapin Antibody (B-3) is a mouse monoclonal IgG2b κ bomapin antibody provided at 200 µg/ml
- raised against amino acids 247-293 mapping within an internal region of bomapin of human origin
- bomapin Antibody (B-3) is recommended for detection of bomapin of human origin by WB, IP, IF and ELISA
- Anti-bomapin Antibody (B-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP is the preferred secondary detection reagent for bomapin Antibody (B-3) for WB applications. This reagent is now offered in a bundle with bomapin Antibody (B-3) (see ordering information below).
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SEE ALSO...
bomapin Antibody (B-3) is a mouse monoclonal IgG2b kappa light chain antibody that detects bomapin protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-bomapin antibody (B-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. bomapin, also known as serine protease inhibitor 10 (PI10), is a member of the serpin superfamily, which plays a crucial role in regulating proteolytic processes within the body. bomapin is highly expressed in human bone marrow cells and is involved in the regulation of various biological functions, including apoptosis, cell migration, and tumor suppression. bomapin interacts with other proteins in the serpin family, which are essential for maintaining homeostasis in both intracellular and extracellular environments. The bomapin gene is located on human chromosome 18q21.3 and encodes a 397 amino acid protein that is particularly significant during hematopoiesis and cellular differentiation. bomapin expression is modulated in monocytic THP-1 and AML-193 cell lines, where treatment with phorbol myristate acetate leads to a reduction in bomapin levels, suggesting a potential role in the early stages of differentiation. bomapin monoclonal antibody (B-3) serves as a valuable tool for researchers investigating the complex regulatory mechanisms of protease activities and their implications in various biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
bomapin Antibody (B-3) References:
- Molecular cloning of bomapin (protease inhibitor 10), a novel human serpin that is expressed specifically in the bone marrow. | Riewald, M. and Schleef, RR. 1995. J Biol Chem. 270: 26754-7. PMID: 7592909
- The intracellular serpin family. | Korpula-Mastalerz, R. and Dubin, A. 1996. Acta Biochim Pol. 43: 419-29. PMID: 8922024
- Cytoplasmic antiproteinase 2 (PI8) and bomapin (PI10) map to the serpin cluster at 18q21.3. | Bartuski, AJ., et al. 1997. Genomics. 43: 321-8. PMID: 9268635
- Expression of bomapin, a novel human serpin, in normal/malignant hematopoiesis and in the monocytic cell lines THP-1 and AML-193. | Riewald, M., et al. 1998. Blood. 91: 1256-62. PMID: 9454755
- SCCA1 and SCCA2 are proteinase inhibitors that map to the serpin cluster at 18q21.3. | Silverman, GA., et al. 1998. Tumour Biol. 19: 480-7. PMID: 9817977
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
bomapin Antibody (B-3) | sc-514795 | 200 µg/ml | $322.00 | |||
bomapin Antibody (B-3): m-IgG2b BP-HRP Bundle | sc-548804 | 200 µg Ab; 10 µg BP | $361.00 | |||
bomapin Antibody (B-3) AC | sc-514795 AC | 500 µg/ml, 25% agarose | $424.00 | |||
bomapin Antibody (B-3) HRP | sc-514795 HRP | 200 µg/ml | $322.00 | |||
bomapin Antibody (B-3) FITC | sc-514795 FITC | 200 µg/ml | $336.00 | |||
bomapin Antibody (B-3) PE | sc-514795 PE | 200 µg/ml | $349.00 | |||
bomapin Antibody (B-3) Alexa Fluor® 488 | sc-514795 AF488 | 200 µg/ml | $364.00 | |||
bomapin Antibody (B-3) Alexa Fluor® 546 | sc-514795 AF546 | 200 µg/ml | $364.00 | |||
bomapin Antibody (B-3) Alexa Fluor® 594 | sc-514795 AF594 | 200 µg/ml | $364.00 | |||
bomapin Antibody (B-3) Alexa Fluor® 647 | sc-514795 AF647 | 200 µg/ml | $364.00 | |||
bomapin Antibody (B-3) Alexa Fluor® 680 | sc-514795 AF680 | 200 µg/ml | $364.00 | |||
bomapin Antibody (B-3) Alexa Fluor® 790 | sc-514795 AF790 | 200 µg/ml | $364.00 |