BMS1 Antibody (A-12): sc-271040

BMS1 Antibody (A-12) is a mouse monoclonal IgG2b kappa light chain antibody that detects BMS1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BMS1 (A-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BMS1 protein, also known as Ribosome biogenesis protein BMS1 homolog, consists of 1,282 amino acids and is encoded by the human gene BMS1. This nuclear protein plays a crucial role in the maturation of the 40S ribosomal subunit within the nucleolus, acting as a molecular switch that facilitates the assembly of the ribosomal components necessary for protein synthesis. The 40S ribosomal subunit is a vital part of the 80S ribosome complex, which is essential for the initiation of translation. Proper functioning of BMS1 ensures efficient production of ribosomes, which are critical for cellular function and growth. Disruptions in ribosome biogenesis can lead to various diseases, including cancer and genetic disorders, highlighting the significance of BMS1 in maintaining cellular homeostasis and overall health.

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BMS1 Antibody (A-12) References:

1. The joining of ribosomal subunits in eukaryotes requires eIF5B.  |  Pestova, TV., et al. 2000. Nature. 403: 332-5. PMID: 10659855
2. Human paralogs of KIAA0187 were created through independent pericentromeric-directed and chromosome-specific duplication mechanisms.  |  Crosier, M., et al. 2002. Genome Res. 12: 67-80. PMID: 11779832
3. Directed proteomic analysis of the human nucleolus.  |  Andersen, JS., et al. 2002. Curr Biol. 12: 1-11. PMID: 11790298
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.  |  Strausberg, RL., et al. 2002. Proc Natl Acad Sci U S A. 99: 16899-903. PMID: 12477932
5. Release of initiation factors from 48S complexes during ribosomal subunit joining and the link between establishment of codon-anticodon base-pairing and hydrolysis of eIF2-bound GTP.  |  Unbehaun, A., et al. 2004. Genes Dev. 18: 3078-93. PMID: 15601822
6. Nucleolar proteome dynamics.  |  Andersen, JS., et al. 2005. Nature. 433: 77-83. PMID: 15635413
7. BMS1 is mutated in aplasia cutis congenita.  |  Marneros, AG. 2013. PLoS Genet. 9: e1003573. PMID: 23785305
8. [BMS1 mutations in aplasia cutis congenita].  |  Dereure, O. 2014. Ann Dermatol Venereol. 141: 161. PMID: 24507215
9. Nucleolar GTPase Bms1 displaces Ttf1 from RFB-sites to balance progression of rDNA transcription and replication.  |  Zhu, Y., et al. 2022. J Mol Cell Biol. 13: 902-917. PMID: 34791311
10. Prevotellaceae produces butyrate to alleviate PD-1/PD-L1 inhibitor-related cardiotoxicity via PPARα-CYP4X1 axis in colonic macrophages.  |  Chen, Y., et al. 2022. J Exp Clin Cancer Res. 41: 1. PMID: 34980222
11. Stability and function of RCL1 are dependent on the interaction with BMS1.  |  Wang, Y., et al. 2024. J Mol Cell Biol. 15: PMID: 37451810
12. LW-213 induces immunogenic tumor cell death via ER stress mediated by lysosomal TRPML1.  |  Zhu, MY., et al. 2023. Cancer Lett. 577: 216435. PMID: 37806516

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BMS1 Antibody (A-12) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-BMS1 Antibody (A-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BMS1 Antibody (A-12) Specifications

Alternate Product Name: BMS1

Product Clone Name: A-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 811-988

Epitope Target: BMS1

Epitope Species: human

Product Reactivity/Detection: BMS1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for BMS1 Antibody (A-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin