BMS 582949 (CAS 623152-17-0)
Alternate Names:
4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propyl-pyrrolo[2,1-f][1,2,4]triazine-6-carboxamide BMS-582949 623152-17-0 BMS-582949 BMS582949 PS540446
CAS Number:
623152-17-0
Molecular Weight:
406.50
Molecular Formula:
C22H26N6O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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BMS 582949 (CAS 623152-17-0) References
- Discovery of 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-N-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (BMS-582949), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases. | Liu, C., et al. 2010. J Med Chem. 53: 6629-39. PMID: 20804198
- Synthesis and evaluation of carbamoylmethylene linked prodrugs of BMS-582949, a clinical p38α inhibitor. | Liu, C., et al. 2013. Bioorg Med Chem Lett. 23: 3028-33. PMID: 23578688
- The effect of BMS-582949, a P38 mitogen-activated protein kinase (P38 MAPK) inhibitor on arterial inflammation: a multicenter FDG-PET trial. | Emami, H., et al. 2015. Atherosclerosis. 240: 490-6. PMID: 25913664
- Prediction of pH dependent absorption using in vitro, in silico, and in vivo rat models: Early liability assessment during lead optimization. | Saxena, A., et al. 2015. Eur J Pharm Sci. 76: 173-80. PMID: 25960252
- Discovery of ((4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carbonyl)(propyl)carbamoyloxy)methyl-2-(4-(phosphonooxy)phenyl)acetate (BMS-751324), a Clinical Prodrug of p38α MAP Kinase Inhibitor. | Liu, C., et al. 2015. J Med Chem. 58: 7775-84. PMID: 26359680
- Glycyrrhizin administration ameliorates Streptococcus aureus-induced acute lung injury. | Yao, L. and Sun, T. 2019. Int Immunopharmacol. 70: 504-511. PMID: 30884430
- ASK1 inhibitor NQDI‑1 decreases oxidative stress and neuroapoptosis via the ASK1/p38 and JNK signaling pathway in early brain injury after subarachnoid hemorrhage in rats. | Duan, J., et al. 2023. Mol Med Rep. 27: PMID: 36633130
- STMN1 Promotes Tumor Metastasis in Non-small Cell Lung Cancer Through Microtubule-dependent And Nonmicrotubule-dependent Pathways. | Zeng, L., et al. 2024. Int J Biol Sci. 20: 1509-1527. PMID: 38385074
- A p38 MAP kinase inhibitor suppresses osteoclastogenesis and alleviates ovariectomy-induced bone loss through the inhibition of bone turnover. | Xu, C., et al. 2024. Biochem Pharmacol. 226: 116391. PMID: 38914317
Inhibitor of:
bradykinin B1 R, CARD14, IL-1β, IL-17C, LPPR2, p38 alpha, p38γ MAPK12, and RELL2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BMS 582949, 5 mg | sc-507348 | 5 mg | $510.00 |