BMPR-II Antibody (E-1): sc-393304

BMPR-II Antibody (E-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects BMPR-II protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BMPR-II (E-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BMPR-II protein plays a crucial role in the bone morphogenetic protein (BMP) signaling pathway, which regulates various biological processes such as cell differentiation, proliferation, and apoptosis. BMPR-II functions as a type II receptor that interacts with type I receptors, BMPR-IA and BMPR-IB, forming a signaling complex that mediates BMP effects on gene expression and morphogenesis. BMPR-II expression occurs in various tissues, including the brain, where proper functioning maintains normal physiological processes. Dysregulation of BMPR-II signaling has been linked to several diseases, including pulmonary arterial hypertension and certain types of cancer, making BMPR-II an important target for therapeutic intervention. anti-BMPR-II antibody (E-1) effectively detects BMPR-II across multiple species and applications, serving as an invaluable tool for researchers studying BMP signaling and its implications in health and disease.

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BMPR-II Antibody (E-1) References:

1. BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia.  |  Beppu, H., et al. 2004. Am J Physiol Lung Cell Mol Physiol. 287: L1241-7. PMID: 15286002
2. The lysosomal inhibitor, chloroquine, increases cell surface BMPR-II levels and restores BMP9 signalling in endothelial cells harbouring BMPR-II mutations.  |  Dunmore, BJ., et al. 2013. Hum Mol Genet. 22: 3667-79. PMID: 23669347
3. Effects of siRNA targeting BMPR-II on the biological activities of human liver cancer cells and its mechanism.  |  Zeng, P., et al. 2014. Cancer Cell Int. 14: 55. PMID: 25002834
4. BMPR-II mutations promote pulmonary arterial hypertension via a hyperinflammatory response.  |  Soon, E., et al. 2015. Clin Med (Lond). 15 Suppl 3: s15. PMID: 26026008
5. Immunoexpression of BMP-2 and BMP-4 and their receptors, BMPR-IA and BMPR-II, in ameloblastomas and adenomatoid odontogenic tumors.  |  Nascimento, MA., et al. 2017. Arch Oral Biol. 73: 223-229. PMID: 27780042
6. TGFβ and BMPRII signalling pathways in the pathogenesis of pulmonary arterial hypertension.  |  Tielemans, B., et al. 2019. Drug Discov Today. 24: 703-716. PMID: 30529762
7. Cloning and characterization of a human type II receptor for bone morphogenetic proteins.  |  Rosenzweig, BL., et al. 1995. Proc Natl Acad Sci U S A. 92: 7632-6. PMID: 7644468
8. Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs.  |  Liu, F., et al. 1995. Mol Cell Biol. 15: 3479-86. PMID: 7791754
9. Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.  |  ten Dijke, P., et al. 1994. J Biol Chem. 269: 16985-8. PMID: 8006002
10. Bone morphogenetic protein type IB receptor is progressively expressed in malignant glioma tumours.  |  Yamada, N., et al. 1996. Br J Cancer. 73: 624-9. PMID: 8605097
11. Expression of serine/threonine kinase receptors including the bone morphogenetic factor type II receptor in the developing and adult rat brain.  |  Söderström, S., et al. 1996. Cell Tissue Res. 286: 269-79. PMID: 8854897
12. Bone morphogenetic protein receptors and activin receptors are highly expressed in ossified ligament tissues of patients with ossification of the posterior longitudinal ligament.  |  Yonemori, K., et al. 1997. Am J Pathol. 150: 1335-47. PMID: 9094990

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BMPR-II Antibody (E-1) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-BMPR-II Antibody (E-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BMPR-II Antibody (E-1) Specifications

Alternate Product Name: BMPR2

Product Clone Name: E-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 61-82

Epitope Target: BMPR-II

Epitope Species: human

Product Reactivity/Detection: BMPR-II

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for BMPR-II Antibody (E-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin