BMP-5 Antibody (MM0117-9G27): sc-517459

BMP-5 Antibody (MM0117-9G27) is a mouse monoclonal IgG2 antibody that detects BMP-5 protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). BMP-5 (MM0117-9G27) antibody is available as a non-conjugated format. Bone morphogenetic proteins (BMPs), including BMP-5, are crucial members of the transforming growth factor-beta (TGFβ) superfamily, playing a significant role in bone and cartilage development regulation. BMP-5 is primarily located in the extracellular matrix and secreted by various cell types, essential for promoting osteogenesis and chondrogenesis. BMP-5 localization in the extracellular matrix enables interaction with specific receptors on target cells, initiating signaling pathways that lead to cellular differentiation and tissue formation. This spatial distribution is vital for proper skeletal structure development and bone homeostasis maintenance. BMP-5 has shown interaction with other BMP family members, such as BMP-2 and BMP-4, which can synergistically enhance biological effects. Understanding BMP-5′s role in these processes is critical for developing therapeutic strategies for bone-related disorders and injuries.

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BMP-5 Antibody (MM0117-9G27) References:

1. Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis.  |  Ozkaynak, E., et al. 1992. J Biol Chem. 267: 25220-7. PMID: 1460021
2. Levels of expression for BMP-7 and several BMP antagonists may play an integral role in a fracture nonunion: a pilot study.  |  Fajardo, M., et al. 2009. Clin Orthop Relat Res. 467: 3071-8. PMID: 19597895
3. The transforming growth factor-beta family.  |  Massagué, J. 1990. Annu Rev Cell Biol. 6: 597-641. PMID: 2177343
4. Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone.  |  Celeste, AJ., et al. 1990. Proc Natl Acad Sci U S A. 87: 9843-7. PMID: 2263636
5. Bone morphogenetic protein-5 and early endothelial outgrowth cells (eEOCs) in acute ischemic kidney injury (AKI) and 5/6-chronic kidney disease.  |  Patschan, D., et al. 2013. Am J Physiol Renal Physiol. 305: F314-22. PMID: 23678046
6. Novel regulators of bone formation: molecular clones and activities.  |  Wozney, JM., et al. 1988. Science. 242: 1528-34. PMID: 3201241
7. Differential expression of BMP inhibitors gremlin and noggin in Hydra suggests distinct roles during budding and patterning of tentacles.  |  Krishnapati, LS., et al. 2020. Dev Dyn. 249: 1470-1485. PMID: 33245611
8. Long bone geometry and strength in adult BMP-5 deficient mice.  |  Mikić, B., et al. 1995. Bone. 16: 445-54. PMID: 7605705
9. Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo.  |  Gitelman, SE., et al. 1994. J Cell Biol. 126: 1595-609. PMID: 8089189
10. A human Mad protein acting as a BMP-regulated transcriptional activator.  |  Liu, F., et al. 1996. Nature. 381: 620-3. PMID: 8637600
11. Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.  |  Zhang, Y., et al. 1996. Nature. 383: 168-72. PMID: 8774881
12. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member.  |  McPherron, AC., et al. 1997. Nature. 387: 83-90. PMID: 9139826

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BMP-5 Antibody (MM0117-9G27) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-BMP-5 Antibody (MM0117-9G27) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BMP-5 Antibody (MM0117-9G27) Specifications

Alternate Product Name: BMP-5

Product Clone Name: MM0117-9G27

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₂

Amino Acids:

Epitope Target: BMP-5

Epitope Species: human

Product Reactivity/Detection: BMP-5

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₂ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for BMP-5 Antibody (MM0117-9G27): N/A