BLOS1 Antibody (E-4): sc-515444

BLOS1 Antibody (E-4) is a mouse monoclonal IgG1 antibody that detects BLOS1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BLOS1 (E-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BLOS1 protein, also known as BLOC1S1 (biogenesis of lysosome-related organelles complex 1 subunit 1), consists of 125 amino acids and is a crucial component of the biogenesis of lysosome-related organelles complex-1 (BLOC1), which is essential for the normal formation of specialized organelles within the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Proper functioning of BLOC1 is vital for endosomal trafficking, influencing the cell-surface abundance of the D2 dopamine receptor, the biogenesis and fusion of synaptic vesicles, and promoting neurite outgrowth. BLOS1 interacts with other subunits of BLOC1, including BLOS2, BLOS3, Dysbindin, Muted, Pallidin, Cappuccino, and Snapin, highlighting its integral role in cellular processes. BLOS1 gene is located on chromosome 12q13.2, a region that encodes over 1,100 genes and is associated with various skeletal deformities, such as hypochondrogenesis and achondrogenesis, underscoring the importance of BLOS1 in both cellular function and developmental biology.

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BLOS1 Antibody (E-4) References:

1. Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1).  |  Starcevic, M. and Dell'Angelica, EC. 2004. J Biol Chem. 279: 28393-401. PMID: 15102850
2. Reinvestigation of the dysbindin subunit of BLOC-1 (biogenesis of lysosome-related organelles complex-1) as a dystrobrevin-binding protein.  |  Nazarian, R., et al. 2006. Biochem J. 395: 587-98. PMID: 16448387
3. The natural history of trisomy 12p.  |  Segel, R., et al. 2006. Am J Med Genet A. 140: 695-703. PMID: 16502429
4. Dysbindin (DTNBP1) and the biogenesis of lysosome-related organelles complex 1 (BLOC-1): main and epistatic gene effects are potential contributors to schizophrenia susceptibility.  |  Morris, DW., et al. 2008. Biol Psychiatry. 63: 24-31. PMID: 17618940
5. Ceap/BLOS2 interacts with BRD7 and selectively inhibits its transcription-suppressing effect on cellular proliferation-associated genes.  |  Sun, J., et al. 2008. Cell Signal. 20: 1151-8. PMID: 18329849
6. Schizophrenia: the 'BLOC' may be in the endosomes.  |  Ryder, PV. and Faundez, V. 2009. Sci Signal. 2: pe66. PMID: 19843956
7. Hermansky-Pudlak protein complexes, AP-3 and BLOC-1, differentially regulate presynaptic composition in the striatum and hippocampus.  |  Newell-Litwa, K., et al. 2010. J Neurosci. 30: 820-31. PMID: 20089890

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BLOS1 Antibody (E-4) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-BLOS1 Antibody (E-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BLOS1 Antibody (E-4) Specifications

Alternate Product Name: BLOS1

Product Clone Name: E-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ lambda light chain

Amino Acids: 54-153

Epitope Target: BLOS1

Epitope Species: human

Product Reactivity/Detection: BLOS1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ lambda light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for BLOS1 Antibody (E-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin