Blood Group Lewis x Antibody (P12): sc-59471

Blood Group Lewis x Antibody (P12) is a mouse monoclonal IgM kappa antibody that detects Blood Group Lewis x protein of human origin by immunofluorescence (IF) and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-Blood Group Lewis x antibody (P12) is available as non-conjugated format. Blood Group Lewis x protein plays a crucial role in cell-cell interactions and is a key player in immune response, as Blood Group Lewis x protein is involved in recognition and binding of cells to selectins, which are important for leukocyte trafficking and adhesion during inflammation. Blood Group Lewis x protein is primarily located on cell surfaces, where Blood Group Lewis x protein contributes to forming a unique carbohydrate profile essential for cellular communication and signaling. Blood Group Lewis x presence on hematopoietic cells is particularly significant, as Blood Group Lewis x protein influences recruitment of immune cells to sites of injury or infection, facilitating effective immune response. Additionally, Blood Group Lewis x carbohydrate determinant is found on both glycolipids and glycoproteins, underscoring Blood Group Lewis x protein′s importance in maintaining proper cellular functions and interactions.

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Blood Group Lewis x Antibody (P12) References:

1. Alteration of sialyl Lewis epitope expression in pterygium.  |  Creuzot-Garcher, C., et al. 1999. Invest Ophthalmol Vis Sci. 40: 1631-6. PMID: 10393028
2. Expression and transcriptional regulation of the human alpha1, 3-fucosyltransferase 4 (FUT4) gene in myeloid and colon adenocarcinoma cell lines.  |  Taniguchi, A., et al. 2000. Biochem Biophys Res Commun. 273: 370-6. PMID: 10873613
3. P-selectin glycoprotein ligand-1 and E-selectin ligand-1 are differentially modified by fucosyltransferases Fuc-TIV and Fuc-TVII in mouse neutrophils.  |  Huang, MC., et al. 2000. J Biol Chem. 275: 31353-60. PMID: 10882744
4. Human alpha (1,3)-fucosyltransferase IV (FUTIV) gene expression is regulated by elk-1 in the U937 cell line.  |  Withers, DA. and Hakomori, SI. 2000. J Biol Chem. 275: 40588-93. PMID: 11006292
5. Potent induction of alpha(1,3)-fucosyltransferase VII in activated CD4+ T cells by TGF-beta 1 through a p38 mitogen-activated protein kinase-dependent pathway.  |  Wagers, AJ. and Kansas, GS. 2000. J Immunol. 165: 5011-6. PMID: 11046029
6. Lewis antigen alterations in gastric cancer precursors.  |  Torrado, J., et al. 1992. Gastroenterology. 102: 424-30. PMID: 1732113
7. Monoclonal antibodies to human colorectal epithelium: markers for differentiation and tumour characterization.  |  Richman, PI. and Bodmer, WF. 1987. Int J Cancer. 39: 317-28. PMID: 2434440
8. Immunochemical characterization of mucins. Polypeptide (M1) and polysaccharide (A and Leb) antigens.  |  Bara, J., et al. 1988. Biochem J. 254: 185-93. PMID: 2460087

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Blood Group Lewis x Antibody (P12) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Blood Group Lewis x Antibody (P12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Blood Group Lewis x Antibody (P12) Specifications

Alternate Product Name: Blood Group Lewis x

Product Clone Name: P12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids:

Epitope Target: Blood Group Lewis x

Epitope Species: human

Product Reactivity/Detection: Blood Group Lewis x (Type 2 chain)

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Blood Group Lewis x Antibody (P12): N/A