Blood Group A antigen Antibody (HE-10): sc-59459

Blood Group A antigen Antibody (HE-10) is a mouse monoclonal IgM antibody that detects Blood Group A antigen protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-Blood Group A antigen antibody (HE-10) is available as the non-conjugated format. Blood Group A antigen plays a crucial role in the immune response and is a key determinant in blood transfusion compatibility, as Blood Group A antigen is one of the primary antigens present on the surface of red blood cells. Blood Group A antigen is formed through the addition of specific carbohydrate structures to glycoproteins and glycolipids, which are essential for cell-cell recognition and signaling. The presence of Blood Group A antigen can influence the body′s immune response, as individuals lacking Blood Group A antigen may produce antibodies against Blood Group A antigen, leading to potential transfusion reactions. Additionally, the modulation of blood group antigens, including Blood Group A antigen, has been observed during malignant transformation, highlighting Blood Group A antigen′s importance in cancer biology and potential implications for targeted therapies. With detection capabilities across various applications, Blood Group A antigen monoclonal antibody (HE-10) serves as an invaluable tool for researchers studying hematology, immunology, and oncology.

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Blood Group A antigen Antibody (HE-10) References:

1. Blood group A antigen is a coreceptor in Plasmodium falciparum rosetting.  |  Barragan, A., et al. 2000. Infect Immun. 68: 2971-5. PMID: 10768996
2. Loss of blood group A antigen expression in bladder cancer caused by allelic loss and/or methylation of the ABO gene.  |  Chihara, Y., et al. 2005. Lab Invest. 85: 895-907. PMID: 15880137
3. Neutralization of blood group A-antigen by a novel anti-A antibody: overcoming ABO-incompatible solid-organ transplantation.  |  Hasegawa, Y., et al. 2008. Transplantation. 85: 378-85. PMID: 18322429
4. Induction of human blood group a antigen expression on mouse cells, using lentiviral gene transduction.  |  Fan, X., et al. 2010. Hum Gene Ther. 21: 877-90. PMID: 20163247
5. Blood Group A antigen expression on cardiac endothelium is highly individualized: possible implications for transplantation.  |  Gehrie, EA., et al. 2013. Cardiovasc Pathol. 22: 251-6. PMID: 23290353
6. Minimal expression of blood group A antigen on thrombocytes from A2 individuals.  |  Skogen, B., et al. 1988. Transfusion. 28: 456-9. PMID: 3138793
7. Red blood cell blood group A antigen level affects the ability of heparin and PfEMP1 antibodies to disrupt Plasmodium falciparum rosettes.  |  Hedberg, P., et al. 2021. Malar J. 20: 441. PMID: 34794445
8. Reduction of blood group A antigen on erythrocytes in a patient with myelodysplastic syndrome harboring somatic mutations in RUNX1 and GATA2.  |  Hayakawa, A., et al. 2022. Transfusion. 62: 469-480. PMID: 34918362
9. The human gut symbiont Ruminococcus gnavus shows specificity to blood group A antigen during mucin glycan foraging: Implication for niche colonisation in the gastrointestinal tract.  |  Wu, H., et al. 2021. PLoS Biol. 19: e3001498. PMID: 34936658
10. Evidence for an expression of blood group A antigen on platelet glycoproteins IV and V.  |  Stockelberg, D., et al. 1996. Transfus Med. 6: 243-8. PMID: 8885154

The preferred Blood Group A antigen antibody is Blood Group A antigen Antibody (Z2A): sc-69951.