Blood Group A antigen Antibody (Z2A): sc-69951

Blood Group A antigen Antibody (Z2A) is a mouse monoclonal IgM antibody that detects Blood Group A antigen of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Anti-Blood Group A antigen antibody (Z2A) is available as the non-conjugated form. Blood Group A antigen plays a crucial role in the immune system by determining blood compatibility during transfusions and organ transplants, which is vital for patient safety and successful medical procedures. Blood Group A antigen is primarily located on the surface of erythrocytes and certain epithelial cells, where Blood Group A antigen contributes to the recognition and interaction of cells within the immune system. Blood Group A antigen can influence the body′s immune response, as Blood Group A antigen is recognized by specific antibodies in individuals with different blood types, highlighting Blood Group A antigen′s importance in transfusion medicine and immunology. Additionally, blood group antigens, including A, B, and H, undergo modulation during malignant cellular transformation, which can affect tumor progression and immune evasion. Understanding the dynamics of Blood Group A antigen is essential for developing targeted therapies and improving patient outcomes in cancer treatment.

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Blood Group A antigen Antibody (Z2A) References:

1. PLTs of blood group A1 donors express increased surface A antigen owing to apheresis and prolonged storage.  |  Julmy, F., et al. 2003. Transfusion. 43: 1378-85. PMID: 14507268
2. Induction of human histo-blood group A antigen expression in mouse cells by gene therapy using lentiviral vectors harbouring human ABH-related glycosyltransferase genes.  |  Fan, X., et al. 2005. Transplant Proc. 37: 265-7. PMID: 15808615
3. Enhanced invasion of blood group A1 erythrocytes by Plasmodium falciparum.  |  Chung, WY., et al. 2005. Mol Biochem Parasitol. 144: 128-30. PMID: 16144724
4. Structural characterization of blood group A glycolipids in blood group A liver tissue in situ perfused with O blood: the dominating presence of type 1 core chain A antigens.  |  Samuelsson, BE., et al. 2006. Xenotransplantation. 13: 160-5. PMID: 16623812
5. Blood group A and B antigen expression in human kidneys correlated to A1/A2/B, Lewis, and secretor status.  |  Breimer, ME., et al. 2006. Transplantation. 82: 479-85. PMID: 16926591
6. Structure of a metal-independent bacterial glycosyltransferase that catalyzes the synthesis of histo-blood group A antigen.  |  Thiyagarajan, N., et al. 2012. Sci Rep. 2: 940. PMID: 23230506
7. Mimotope selection of blood group A antigen from a phage display 15-mer peptide library.  |  Tang, ZM., et al. 2013. Transpl Immunol. 29: 39-42. PMID: 23806589
8. Repetitive A epitope (type 3 chain A) defined by blood group A1-specific monoclonal antibody TH-1: chemical basis of qualitative A1 and A2 distinction.  |  Clausen, H., et al. 1985. Proc Natl Acad Sci U S A. 82: 1199-203. PMID: 2579390
9. Inhibition of the blood group A1 and A2 gene-specified N-acetyl-alpha-D-galactosaminyltransferases by uridine diphosphate D-galactose.  |  Race, C. and Watkins, WM. 1974. Carbohydr Res. 37: 239-44. PMID: 4429970
10. A-active trisaccharides isolated from A1 and A2 blood-group-specific glycoproteins.  |  Donald, AS. 1981. Eur J Biochem. 120: 243-9. PMID: 6172274
11. Another case of a lymphocytotoxic antibody with blood group A1 Leb and A Led associated specificity.  |  Staub Nielsen, L., et al. 1983. Tissue Antigens. 21: 177-83. PMID: 6190260
12. Trisaccharides from blood group A1 and A2 mucous glycoproteins.  |  Donald, AS. 1982. Adv Exp Med Biol. 144: 49-51. PMID: 7080941

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Blood Group A antigen Antibody (Z2A) has 16 citations in a variety of scientific publications.

Primary antibodies like Anti-Blood Group A antigen Antibody (Z2A) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Blood Group A antigen Antibody (Z2A) Specifications

Alternate Product Name: Blood Group A antigen

Product Clone Name: Z2A

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM

Amino Acids:

Epitope Target: Blood Group A antigen

Epitope Species: human

Product Reactivity/Detection: Blood Group A antigen

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 100 µg IgM in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 16 citations in various scientific publications

Available Conjugates/Forms for Blood Group A antigen Antibody (Z2A): N/A