BLC Antibody (946): sc-73740

BLC Antibody (946) is a mouse monoclonal IgG1 antibody that detects BLC protein of human origin by western blotting (WB), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Anti-BLC antibody (946) is available as a non-conjugated format. BLC, also known as SCYB13, BCA1, or CXCL13 (C-X-C motif chemokine 13), is a 109 amino acid protein that plays a crucial role in the immune system by facilitating the organization of B cells within lymphoid follicles. BLC promotes calcium influx and chemotaxis of cells expressing Burkitt′s lymphoma receptor 1 (BLR-1), helping maintain lymphoid tissue architecture for effective immune responses. BLC is predominantly secreted and expressed at highest levels in the liver, followed by the spleen, lymph nodes, appendix, and stomach, with lower levels in the salivary gland, mammary gland, and fetal spleen. As a member of the intercrine alpha (chemokine CXC) family, BLC directs leukocyte migration during inflammation and is involved in lymphocyte homing into follicles and T-cell zones through interactions with seven transmembrane G protein-coupled receptors.

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BLC Antibody (946) References:

1. Serum BLC/CXCL13 concentrations and renal expression of CXCL13/CXCR5 in patients with systemic lupus erythematosus and lupus nephritis.  |  Lee, HT., et al. 2010. J Rheumatol. 37: 45-52. PMID: 19955043
2. Increased cerebrospinal fluid concentrations of the chemokine CXCL13 in active MS.  |  Sellebjerg, F., et al. 2009. Neurology. 73: 2003-10. PMID: 19996075
3. CXCL13 expression in Chlamydia trachomatis infection of the female reproductive tract.  |  King, M., et al. 2009. Drugs Today (Barc). 45 Suppl B: 125-34. PMID: 20011704
4. The chemokine CXCL13 is a key regulator of B cell recruitment to the cerebrospinal fluid in acute Lyme neuroborreliosis.  |  Rupprecht, TA., et al. 2009. J Neuroinflammation. 6: 42. PMID: 20042073
5. Evaluation of the presence of B-cell attractant chemokines in chronic rhinosinusitis.  |  Patadia, M., et al. 2010. Am J Rhinol Allergy. 24: 11-6. PMID: 20109310
6. Ectopic and high CXCL13 chemokine expression in myasthenia gravis with thymic lymphoid hyperplasia.  |  Shiao, YM., et al. 2010. J Neuroimmunol. 221: 101-6. PMID: 20223524
7. IL8 and CXCL13 are potent chemokines for the recruitment of human neural precursor cells across brain endothelial cells.  |  Weiss, N., et al. 2010. J Neuroimmunol. 223: 131-4. PMID: 20400187
8. PI3Kp110-, Src-, FAK-dependent and DOCK2-independent migration and invasion of CXCL13-stimulated prostate cancer cells.  |  El Haibi, CP., et al. 2010. Mol Cancer. 9: 85. PMID: 20412587