BIN2 Antibody (E-2): sc-376391
- BIN2 Antibody (E-2) is a mouse monoclonal IgG1 κ BIN2 antibody provided at 200 µg/ml
- raised against amino acids 40-109 mapping near the N-terminus of BIN2 of human origin
- BIN2 Antibody (E-2) is recommended for detection of BIN2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-BIN2 Antibody (E-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for BIN2 Antibody (E-2) for WB and IHC(P) applications. This reagent is now offered in a bundle with BIN2 Antibody (E-2) (see ordering information below).
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SEE ALSO...
BIN2 Antibody (E-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects BIN2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). BIN2 (E-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BIN2, also known as Breast cancer-associated protein 1, is a 565 amino acid protein that plays a crucial role in cellular processes, particularly in hematopoietic tissues, showing high expression levels in the spleen, thymus, colon, placenta, and various lymphoid and granulocytic cells. BIN2 interacts with BIN1, another BAR protein sharing 61% sequence similarity; however, unlike BIN1, which functions as a tumor suppressor and interacts with transcription factors like c-Myc, BIN2 lacks these features. Two isoforms of BIN2, resulting from alternative splicing, add complexity to its functional roles, making BIN2 important for understanding various biological processes and potential implications in diseases, including cancer.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
BIN2 Antibody (E-2) References:
- Mechanisms of apoptosis by c-Myc. | Prendergast, GC. 1999. Oncogene. 18: 2967-87. PMID: 10378693
- Bin2, a functionally nonredundant member of the BAR adaptor gene family. | Ge, K. and Prendergast, GC. 2000. Genomics. 67: 210-20. PMID: 10903846
- The c-Myc-interacting adaptor protein Bin1 activates a caspase-independent cell death program. | Elliott, K., et al. 2000. Oncogene. 19: 4669-84. PMID: 11032017
- Bin1 mediates apoptosis by c-Myc in transformed primary cells. | DuHadaway, JB., et al. 2001. Cancer Res. 61: 3151-6. PMID: 11306501
- The BAR-domain family of proteins: a case of bending and binding? | Habermann, B. 2004. EMBO Rep. 5: 250-5. PMID: 14993925
- BAR domains and membrane curvature: bringing your curves to the BAR. | Gallop, JL. and McMahon, HT. 2005. Biochem Soc Symp. 223-31. PMID: 15649145
- Direct observation of Bin/amphiphysin/Rvs (BAR) domain-induced membrane curvature by means of molecular dynamics simulations. | Blood, PD. and Voth, GA. 2006. Proc Natl Acad Sci U S A. 103: 15068-72. PMID: 17008407
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BIN2 Antibody (E-2) | sc-376391 | 200 µg/ml | $322.00 | |||
BIN2 Antibody (E-2): m-IgG Fc BP-HRP Bundle | sc-526026 | 200 µg Ab; 10 µg BP | $361.00 | |||
BIN2 Antibody (E-2) AC | sc-376391 AC | 500 µg/ml, 25% agarose | $424.00 | |||
BIN2 Antibody (E-2) HRP | sc-376391 HRP | 200 µg/ml | $322.00 | |||
BIN2 Antibody (E-2) FITC | sc-376391 FITC | 200 µg/ml | $336.00 | |||
BIN2 Antibody (E-2) PE | sc-376391 PE | 200 µg/ml | $349.00 | |||
BIN2 Antibody (E-2) Alexa Fluor® 488 | sc-376391 AF488 | 200 µg/ml | $364.00 | |||
BIN2 Antibody (E-2) Alexa Fluor® 546 | sc-376391 AF546 | 200 µg/ml | $364.00 | |||
BIN2 Antibody (E-2) Alexa Fluor® 594 | sc-376391 AF594 | 200 µg/ml | $364.00 | |||
BIN2 Antibody (E-2) Alexa Fluor® 647 | sc-376391 AF647 | 200 µg/ml | $364.00 | |||
BIN2 Antibody (E-2) Alexa Fluor® 680 | sc-376391 AF680 | 200 µg/ml | $364.00 | |||
BIN2 Antibody (E-2) Alexa Fluor® 790 | sc-376391 AF790 | 200 µg/ml | $364.00 |