Bim Antibody (Ham 151-149): sc-130511

Bim Antibody (Ham 151-149) is a Armenian hamster monoclonal IgG1 antibody designed to detect Bim protein, also known as BCL2L11, a pivotal pro-apoptotic member of the Bcl-2 protein family. Bim plays a crucial role in the regulation of apoptosis by antagonizing the function of anti-apoptotic proteins such as Bcl-XL, thereby promoting programmed cell death and maintaining cellular homeostasis. Anti-Bim antibody (Ham 151-149) targets an epitope formed by the Bim and Bcl-XL complex, specifically recognizing the Bcl-XL complex of mouse origin, ensuring precise detection in mouse models. Bim exists in three isoforms, BimS, BimL, and BimEL, each differing in their pro-apoptotic activity, with BimEL being the most potent in triggering apoptosis. The function of Bim is vital in processes such as development, immune cell regulation, and the elimination of damaged or unwanted cells, making Bim a key player in preventing tumorigenesis and autoimmune diseases. Bim monoclonal antibody (Ham 151-149) is optimized for the detection of mouse Bim via immunoprecipitation (IP) and flow cytometry (FCM), providing reliable performance in various experimental settings. By targeting Bim, researchers can gain valuable insights into apoptotic pathways and cell survival mechanisms, which are essential for understanding disease mechanisms and developing therapeutic strategies.

The preferred Bim antibody is Bim Antibody (H-5): sc-374358.