BI-1 Antibody (430): sc-52895

BI-1 Antibody (430) is a mouse monoclonal IgG2b antibody that detects BI-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunofluorescence (IF), and immunohistochemistry. Anti-BI-1 antibody (430) is available in a non-conjugated form, allowing for versatile experimental use. BI-1, also known as Bax inhibitor 1 or testis enhanced gene transcript (TEGT), plays a crucial role in regulating cell death pathways influenced by Bcl-2 and Bax, making BI-1 essential for maintaining cellular homeostasis. This integral membrane protein is characterized by six membrane-spanning segments and primarily localizes to intracellular membranes, which positions BI-1 to effectively modulate apoptotic signals within the cell. The human version of BI-1 consists of 237 amino acids and interacts with other key proteins in apoptosis regulation, such as Bcl-2 and Bcl-XL. Notably, when BI-1 is overexpressed in mammalian cells, BI-1 can inhibit apoptosis triggered by various stressors, including Bax, etoposide, staurosporine, and deprivation of growth factors, while BI-1′s antisense counterpart induces apoptosis. This multifaceted role of BI-1 underscores BI-1′s importance in cancer research and therapeutic development, making BI-1 (430) monoclonal antibody a valuable tool for scientists studying cell survival mechanisms.

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BI-1 Antibody (430) References:

1. Preliminary characterization of the protein encoded by human testis-enhanced gene transcript (TEGT).  |  Cowling, RT. and Birnboim, HC. 1998. Mol Membr Biol. 15: 177-87. PMID: 10087504
2. The Bax inhibitor-1 gene is differentially regulated in adult testis and developing lung by two alternative TATA-less promoters.  |  Jean, JC., et al. 1999. Genomics. 57: 201-8. PMID: 10198159
3. Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells.  |  Grzmil, M., et al. 2003. Am J Pathol. 163: 543-52. PMID: 12875974
4. BAX Inhibitor-1, an ancient cell death suppressor in animals and plants with prokaryotic relatives.  |  Hückelhoven, R. 2004. Apoptosis. 9: 299-307. PMID: 15258461
5. BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress.  |  Chae, HJ., et al. 2004. Mol Cell. 15: 355-66. PMID: 15304216
6. BI-1 protects cells from oxygen glucose deprivation by reducing the calcium content of the endoplasmic reticulum.  |  Westphalen, BC., et al. 2005. Cell Death Differ. 12: 304-6. PMID: 15650756
7. Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast.  |  Xu, Q. and Reed, JC. 1998. Mol Cell. 1: 337-46. PMID: 9660918

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BI-1 Antibody (430) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-BI-1 Antibody (430) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BI-1 Antibody (430) Specifications

Alternate Product Name: BI-1

Product Clone Name: 430

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids:

Epitope Target: BI-1

Epitope Species: human

Product Reactivity/Detection: BI-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF, IHC(P)

Vialing Information: Each vial contains 50 µg IgG_2b in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for BI-1 Antibody (430): N/A