Date published: 2025-10-20

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BETd-246 (CAS 2140289-17-2)

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Datasheets
CAS Number:
2140289-17-2
Molecular Weight:
946.040
Molecular Formula:
C48H55N11O10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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BETd-246 (CAS 2140289-17-2) References

  1. Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer.  |  Bai, L., et al. 2017. Cancer Res. 77: 2476-2487. PMID: 28209615
  2. Targeting bromodomain and extraterminal proteins in breast cancer.  |  Sahni, JM. and Keri, RA. 2018. Pharmacol Res. 129: 156-176. PMID: 29154989
  3. Targeting BCL-xL improves the efficacy of bromodomain and extra-terminal protein inhibitors in triple-negative breast cancer by eliciting the death of senescent cells.  |  Gayle, SS., et al. 2019. J Biol Chem. 294: 875-886. PMID: 30482844
  4. Targeting Brd4 for cancer therapy: inhibitors and degraders.  |  Duan, Y., et al. 2018. Medchemcomm. 9: 1779-1802. PMID: 30542529
  5. Characterizing the Therapeutic Potential of a Potent BET Degrader in Merkel Cell Carcinoma.  |  Choi, JE., et al. 2019. Neoplasia. 21: 322-330. PMID: 30797188
  6. PROTACs: great opportunities for academia and industry.  |  Sun, X., et al. 2019. Signal Transduct Target Ther. 4: 64. PMID: 31885879
  7. Controlled Delivery of BET-PROTACs: In Vitro Evaluation of MZ1-Loaded Polymeric Antibody Conjugated Nanoparticles in Breast Cancer.  |  Cimas, FJ., et al. 2020. Pharmaceutics. 12: PMID: 33086530
  8. Targeting Bromodomain and Extraterminal Proteins for Drug Discovery: From Current Progress to Technological Development.  |  Tang, P., et al. 2021. J Med Chem. 64: 2419-2435. PMID: 33616410
  9. Small-Molecule PROTACs for Cancer Immunotherapy.  |  Liu, Z., et al. 2022. Molecules. 27: PMID: 36080223
  10. Chemically induced degradation of epigenetic targets.  |  Kabir, M., et al. 2023. Chem Soc Rev. 52: 4313-4342. PMID: 37314393

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

BETd-246, 5 mg

sc-507288
5 mg
$1071.00