beta 2 Adrenergic Receptor/ADRB2/β2-AR Antibody (E-3): sc-271322

β2-AR Antibody (E-3) is a mouse monoclonal IgG2b kappa light chain antibody that detects the beta 2-AR protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-β2-AR antibody (E-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The beta 2-adrenergic receptor (β2-AR) plays a crucial role in mediating the physiological effects of catecholamines, such as epinephrine and norepinephrine, which are vital for the regulation of cardiovascular function, smooth muscle relaxation, and metabolic processes. Located primarily in the plasma membrane of various cell types, including cardiac myocytes and bronchial smooth muscle cells, β2-AR is essential for the modulation of heart rate and airway dilation, making β2-AR a significant target for therapeutic interventions in conditions like asthma and heart failure. β2-AR′s structure, characterized by seven transmembrane helices, allows β2-AR to interact with G proteins, leading to the activation of intracellular signaling pathways that influence cellular responses. Understanding β2-AR signaling dynamics is critical for developing drugs that can selectively target this receptor to enhance therapeutic efficacy while minimizing side effects.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-beta 2 Adrenergic Receptor/ADRB2/β2-AR Antibody (E-3) has 15 citations in a variety of scientific publications.

Primary antibodies like Anti-beta 2 Adrenergic Receptor/ADRB2/β2-AR Antibody (E-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

beta 2 Adrenergic Receptor/ADRB2/β2-AR Antibody (E-3) Specifications

Alternate Product Name: ADRB2

Product Clone Name: E-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 338-413

Epitope Target: β₂-AR

Epitope Species: human

Product Reactivity/Detection: β₂-AR

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 15 citations in various scientific publications

Available Conjugates/Forms for beta 2 Adrenergic Receptor/ADRB2/β2-AR Antibody (E-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred beta 2 Adrenergic Receptor/ADRB2/β2-AR antibody is beta 2 Adrenergic Receptor/ADRB2/β2-AR Antibody (R11E1): sc-81577.