Molecular structure of β, γ-Methyleneadenosine 5′-triphosphate disodium salt, CAS Number: 7414-56-4
β, γ-Methyleneadenosine 5′-triphosphate disodium salt (CAS 7414-56-4)
CAS Number:
7414-56-4
Purity:
≥95%
Molecular Weight:
549.17
Molecular Formula:
C11H16N5O12P3•2Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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β, γ-Methyleneadenosine 5′-triphosphate disodium salt, also known as β,γ-MeA-TP, is a nucleotide analog derived from adenosine 5′-triphosphate (ATP). It exhibits potent inhibitory effects on adenylate cyclase, an essential enzyme involved in signal transduction pathways. Selective P2X purinoceptor agonist which is more potent than ATP and less potent than α, β-methylene-L-adenosine 5′-triphosphate.
β, γ-Methyleneadenosine 5′-triphosphate disodium salt (CAS 7414-56-4) References
- Regulation of L- and N-types of Ca2+ channels by intracellular ATP4- in frog dorsal root ganglion neurons. | Yuki, T., et al. 1999. Pflugers Arch. 438: 117-24. PMID: 10370096
- Evidence that the plant cannabinoid cannabigerol is a highly potent alpha2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist. | Cascio, MG., et al. 2010. Br J Pharmacol. 159: 129-41. PMID: 20002104
- Expression of P2X₁ and P2X₄ receptors in rat trigeminal ganglion neurons. | Kuroda, H., et al. 2012. Neuroreport. 23: 752-6. PMID: 22785548
- Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery. | Wang, Y., et al. 2016. FEBS J. 283: 102-11. PMID: 26462166
- Structural Insights into the Pharmacophore of Vinca Domain Inhibitors of Microtubules. | Wang, Y., et al. 2016. Mol Pharmacol. 89: 233-42. PMID: 26660762
- Direct modulation of TRPM4 and TRPM3 channels by the phospholipase C inhibitor U73122. | Leitner, MG., et al. 2016. Br J Pharmacol. 173: 2555-69. PMID: 27328745
- Polymorphs, co-crystal structure and pharmacodynamics study of MBRI-001, a deuterium-substituted plinabulin derivative as a tubulin polymerization inhibitor. | Ma, M., et al. 2019. Bioorg Med Chem. 27: 1836-1844. PMID: 30910474
- Structural Basis of Sarco/Endoplasmic Reticulum Ca2+-ATPase 2b Regulation via Transmembrane Helix Interplay. | Inoue, M., et al. 2019. Cell Rep. 27: 1221-1230.e3. PMID: 31018135
- Salivary extracellular vesicles can modulate purinergic signalling in oral tissues by combined ectonucleoside triphosphate diphosphohydrolases and ecto-5'-nucleotidase activities. | González, DA., et al. 2020. Mol Cell Biochem. 463: 1-11. PMID: 31531757
- Reversible binding of the anticancer drug KXO1 (tirbanibulin) to the colchicine-binding site of β-tubulin explains KXO1's low clinical toxicity. | Niu, L., et al. 2019. J Biol Chem. 294: 18099-18108. PMID: 31628188
- A Selective Fluorogenic Peptide Substrate for the Human Mitochondrial ATP-Dependent Protease Complex ClpXP. | Sha, Z., et al. 2020. Chembiochem. 21: 2037-2048. PMID: 32180333
- High-resolution X-ray structure of three microtubule-stabilizing agents in complex with tubulin provide a rationale for drug design. | Xiao, Q., et al. 2021. Biochem Biophys Res Commun. 534: 330-336. PMID: 33272565
- Purinergic smooth muscle contractions in the human prostate: estimation of relevance and characterization of different agonists. | Spek, A., et al. 2021. Naunyn Schmiedebergs Arch Pharmacol. 394: 1113-1131. PMID: 33427927
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
β, γ-Methyleneadenosine 5′-triphosphate disodium salt, 5 mg | sc-253042 | 5 mg | $93.00 | |||
β, γ-Methyleneadenosine 5′-triphosphate disodium salt, 10 mg | sc-253042A | 10 mg | $189.00 |