β-dystroglycan Antibody (56): sc-135891
- β-dystroglycan Antibody (56) is a mouse monoclonal IgG2a provided at 50 µg/0.5 ml
- raised against amino acids 655-767 of β-dystroglycan of human origin
- recommended for detection of β-dystroglycan of human origin by WB and IP
- See β-dystroglycan (4F7): sc-33702 for β-dystroglycan antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for β-dystroglycan Antibody (56). This work is in progress.
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β-dystroglycan Antibody (56) is a mouse monoclonal IgG2a antibody that detects β-dystroglycan in human samples through western blotting (WB) and immunoprecipitation (IP) applications. β-dystroglycan plays a crucial role in the formation of the dystrophin-associated protein complex, which is essential for maintaining the structural integrity of muscle cells. β-dystroglycan is primarily located at the sarcolemma, where β-dystroglycan interacts with dystrophin and other associated proteins to provide mechanical stability during muscle contraction. Proper functioning of β-dystroglycan is vital for muscle health, as mutations or disruptions in β-dystroglycan expression can lead to various muscular dystrophies and other neuromuscular disorders. Additionally, β-dystroglycan is involved in the clustering of nicotinic acetylcholine receptors at the neuromuscular junction, which is critical for effective synaptic transmission and muscle activation. Anti-β-dystroglycan antibody (56) enables researchers to gain valuable insights into β-dystroglycan′s role in muscle physiology and pathology, making anti-β-dystroglycan antibody (56) an indispensable tool for studies focused on muscle-related diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
β-dystroglycan Antibody (56) References:
- The interaction of dystrophin with beta-dystroglycan is regulated by tyrosine phosphorylation. | Ilsley, JL., et al. 2001. Cell Signal. 13: 625-32. PMID: 11495720
- Identification of the beta-dystroglycan binding epitope within the C-terminal region of alpha-dystroglycan. | Sciandra, F., et al. 2001. Eur J Biochem. 268: 4590-7. PMID: 11502221
- Nuclear import of β-dystroglycan is facilitated by ezrin-mediated cytoskeleton reorganization. | Vásquez-Limeta, A., et al. 2014. PLoS One. 9: e90629. PMID: 24599031
- Absence of α- and β-dystroglycan is associated with Walker-Warburg syndrome. | Riemersma, M., et al. 2015. Neurology. 84: 2177-82. PMID: 25934851
- Control of nuclear β-dystroglycan content is crucial for the maintenance of nuclear envelope integrity and function. | Vélez-Aguilera, G., et al. 2018. Biochim Biophys Acta Mol Cell Res. 1865: 406-420. PMID: 29175376
- Mobility shift of beta-dystroglycan as a marker of GMPPB gene-related muscular dystrophy. | Sarkozy, A., et al. 2018. J Neurol Neurosurg Psychiatry. 89: 762-768. PMID: 29437916
- The Molecular Basis and Biologic Significance of the β-Dystroglycan-Emerin Interaction. | Gómez-Monsivais, WL., et al. 2020. Int J Mol Sci. 21: PMID: 32824881
- The Association Between β-Dystroglycan in Airway Smooth Muscle and Eosinophils in Allergic Asthma. | Shareef, SH., et al. 2021. Inflammation. 44: 1060-1068. PMID: 33566255
- Identification and characterization of the dystrophin anchoring site on beta-dystroglycan. | Jung, D., et al. 1995. J Biol Chem. 270: 27305-10. PMID: 7592992
- Muscular dystrophy associated with beta-Dystroglycan deficiency. | Salih, MA., et al. 1996. Ann Neurol. 40: 925-8. PMID: 9007100
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
β-dystroglycan Antibody (56) | sc-135891 | 50 µg/0.5 ml | $322.00 |