β-defensin 3 Antibody (L3-18b-E1): sc-59495

β-defensin 3 Antibody (L3-18b-E1) is a mouse monoclonal IgG1 kappa light chain antibody that detects the beta-defensin 3 protein of human origin by enzyme-linked immunosorbent assay (ELISA). β-defensin 3 (L3-18b-E1) antibody is available as a non-conjugated antibody. Beta-defensin 3, a member of the defensin family, plays a crucial role in the innate immune response due to its broad-spectrum antimicrobial activity, which is vital for protecting the host from various pathogens. Beta-defensin 3 is primarily produced in mucosal epithelia and neutrophils, and expression is developmentally regulated, highlighting its importance in immune defense mechanisms. Notably, beta-defensin 3 is localized in the respiratory system and is also found in lower levels within the epithelial cells of the intestine and lung, where beta-defensin 3 contributes to the first line of defense against microbial invasion. The regulation of beta-defensin 3 is particularly significant during inflammatory responses, as expression can be upregulated in response to stimuli such as lipopolysaccharide, thereby enhancing mucosal immunity. Anti-beta-defensin 3 antibody (L3-18b-E1) serves as an essential tool for researchers studying the immune response and the role of antimicrobial peptides in health and disease.

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β-defensin 3 Antibody (L3-18b-E1) References:

1. Mouse beta-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs.  |  Bals, R., et al. 1999. Infect Immun. 67: 3542-7. PMID: 10377137
2. Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6.  |  Yang, D., et al. 1999. Science. 286: 525-8. PMID: 10521347
3. The human beta-defensin-3, an antibacterial peptide with multiple biological functions.  |  Dhople, V., et al. 2006. Biochim Biophys Acta. 1758: 1499-512. PMID: 16978580
4. Dysregulation of human beta-defensin-3 expression in the peripheral blood of patients with sepsis.  |  Al Mansour, N., et al. 2021. SAGE Open Med. 9: 20503121211041515. PMID: 34457302
5. Human β-Defensin-3 is Associated With Platelet-Derived Extracellular Vesicles and is a Potential Contributor to Endothelial Dysfunction.  |  Panigrahi, S., et al. 2022. Front Mol Biosci. 9: 824954. PMID: 35355507
6. Human β-defensin-3 attenuates atopic dermatitis-like inflammation through autophagy activation and the aryl hydrocarbon receptor signaling pathway.  |  Peng, G., et al. 2022. J Clin Invest. 132: PMID: 35834333
7. Alterations in fecal β-defensin-3 secretion as a marker of instability of the gut microbiota.  |  Saqib, Z., et al. 2023. Gut Microbes. 15: 2233679. PMID: 37464450
8. Human β-Defensin 3 Inhibition of P. gingivalis LPS-Induced IL-1β Production by BV-2 Microglia through Suppression of Cathepsins B and L.  |  Inoue, E., et al. 2024. Cells. 13: PMID: 38334675
9. Human airway epithelia express a beta-defensin.  |  McCray, PB. and Bentley, L. 1997. Am J Respir Cell Mol Biol. 16: 343-9. PMID: 9070620
10. The human beta-defensin-1 and alpha-defensins are encoded by adjacent genes: two peptide families with differing disulfide topology share a common ancestry.  |  Liu, L., et al. 1997. Genomics. 43: 316-20. PMID: 9268634
11. Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation.  |  Liu, L., et al. 1998. Gene. 222: 237-44. PMID: 9831658
12. A novel mouse beta defensin, Defb2, which is upregulated in the airways by lipopolysaccharide.  |  Morrison, GM., et al. 1999. FEBS Lett. 442: 112-6. PMID: 9923615

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-β-defensin 3 Antibody (L3-18b-E1) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-β-defensin 3 Antibody (L3-18b-E1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

β-defensin 3 Antibody (L3-18b-E1) Specifications

Alternate Product Name: β-defensin 3

Product Clone Name: L3-18b-E1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 6-22

Epitope Target: β-defensin 3

Epitope Species: human

Product Reactivity/Detection: β-defensin 3

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: ELISA

Vialing Information: Each vial contains 50 µg IgG₁ kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for β-defensin 3 Antibody (L3-18b-E1): N/A