beta-catenin Antibody (BDI870): sc-59896

β-catenin Antibody (BDI870) is a mouse monoclonal IgG1 antibody developed against full-length human β-catenin, effectively detecting β-catenin from mouse, rat, and human origins in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). β-Catenin, also known as catenin beta-1 or CTNNB1, is a multifunctional protein that plays a crucial role in cell-cell adhesion and gene transcription regulation. At the plasma membrane, β-catenin binds to the intracellular tail of cadherins, forming catenin-cadherin complexes that maintain tissue architecture and cellular adhesion. In the cytoplasm, β-catenin serves as a central mediator of the Wnt signaling pathway, where stabilization and nuclear translocation regulate the transcription of genes involved in cell proliferation, differentiation, and survival. Dysregulation of β-catenin levels or activity has been implicated in various diseases, including cancers, due to β-catenin′s role in controlling key cellular processes. Structurally, β-catenin consists of armadillo repeats that facilitate interaction with multiple binding partners, ensuring versatility in diverse cellular contexts. The dual functions of β-catenin in adhesion and signaling underscore importance in maintaining cellular homeostasis and coordinating developmental pathways. Anti-β-catenin antibody (BDI870) provides a reliable tool for studying these essential functions, offering specificity and versatility for diverse experimental needs.

The preferred beta-catenin antibody is beta-catenin Antibody (E-5): sc-7963.