beta-catenin Antibody (B-9): sc-376841

β-catenin Antibody (B-9) is a mouse monoclonal IgG3 kappa light chain antibody engineered to detect β-catenin, also known as CTNNB1, a critical protein involved in cellular adhesion and the regulation of gene transcription. β-catenin plays an essential role in the formation and stabilization of adherens junctions by binding to the intracellular cytoplasmic tail of cadherins, such as E-cadherin, thereby maintaining tissue architecture and integrity. Additionally, β-catenin is a key component of the Wnt signaling pathway, where β-catenin interacts with transcription factors to control cell proliferation, differentiation, and migration, processes that are vital for normal development and are frequently disrupted in various cancers. β-catenin monoclonal antibody (B-9) targets a specific epitope located between amino acids 755-781 at the C-terminus of human β-catenin, ensuring precise and reliable detection. Anti-β-catenin antibody (B-9) demonstrates broad species reactivity, effectively recognizing β-catenin from mouse, rat, human, and avian origins, as well as additional species including equine, canine, bovine, and porcine. β-catenin monoclonal antibody (B-9) is validated for multiple applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA), making β-catenin monoclonal antibody (B-9) a versatile tool for diverse research needs. By facilitating the exploration of β-catenin′s dual roles in cell adhesion and signaling pathways, anti-β-catenin antibody (B-9) is indispensable for researchers studying the molecular mechanisms underlying cellular communication, development, and oncogenesis.

The preferred beta-catenin antibody is beta-catenin Antibody (E-5): sc-7963.