beta-catenin Antibody (10H8): sc-65480

β-catenin Antibody (10H8) is a mouse monoclonal IgG2a antibody that targets amino acids 769–781 of human β-catenin, a key protein also known as catenin beta-1 or armadillo in Drosophila. β-catenin is integral to both cell–cell adhesion and the Wnt signaling pathway, owing to its unique structure, which includes a central region of 12 armadillo repeats that form a superhelical shape. This structural feature allows β-catenin to interact with diverse partners, including E-cadherin at adherens junctions, where β-catenin connects the cytoplasmic tail of E-cadherin to the actin cytoskeleton, ensuring tissue cohesion and signal transduction. In Wnt signaling, β-catenin stabilizes in the cytoplasm and translocates to the nucleus to regulate genes crucial for cell growth and differentiation. Dysregulation of β-catenin is associated with abnormal cellular processes, highlighting β-catenin′s importance in maintaining cellular homeostasis. Anti-β-catenin antibody (10H8) is validated for applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF) and is reactive with β-catenin from human, mouse, and rat sources. By specifically targeting the C-terminus of β-catenin, β-catenin monoclonal antibody (10H8) offers reliable detection for research into adhesion mechanisms and signaling pathways. Anti-β-catenin antibody (10H8) is an essential tool for studying the structural and functional dynamics of this versatile protein.

The preferred beta-catenin antibody is beta-catenin Antibody (E-5): sc-7963.