β-Amyloid Antibody (D-11): sc-374527
- β-Amyloid Antibody (D-11) is a mouse monoclonal IgG1 κ, cited in 13 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 663-687 at the C-terminus of β-Amyloid of human origin
- beta-Amyloid Antibody (D-11) is recommended for detection of 4 kDa β-Amyloid and Amyloid A4 of mouse, rat, human and origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- Anti-beta-Amyloid Antibody (D-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for β-Amyloid Antibody (D-11) for WB and IHC(P) applications. This reagent is now offered in a bundle with β-Amyloid Antibody (D-11) (see ordering information below).
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β-Amyloid Antibody (D-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects β-Amyloid in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). β-Amyloid (D-11) antibody is available in both non-conjugated and multiple conjugated forms, such as agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates. β-Amyloid, derived from proteolytic cleavage of amyloid precursor protein (APP), plays a critical role in Alzheimer′s disease pathogenesis, as accumulation leads to neurotoxic plaques and neurofibrillary tangles in the brain. β-Amyloid shows significance beyond neurodegenerative diseases, with implications in type II diabetes and Down syndrome. β-Amyloid presence in human platelets underscores broader biological importance. APP undergoes alternative splicing, producing several isoforms, adding complexity to function and regulation. β-Amyloid interacts with proteins including APLP1 and APLP2, which share structural similarities to APP and may influence processing and aggregation. Understanding β-Amyloid dynamics and interactions remains crucial for developing therapeutic strategies against Alzheimer′s disease and related disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
β-Amyloid Antibody (D-11) | sc-374527 | 200 µg/ml | $322.00 | |||
β-Amyloid Antibody (D-11): m-IgG Fc BP-HRP Bundle | sc-525975 | 200 µg Ab; 10 µg BP | $361.00 | |||
β-Amyloid Antibody (D-11) AC | sc-374527 AC | 500 µg/ml, 25% agarose | $424.00 | |||
β-Amyloid Antibody (D-11) HRP | sc-374527 HRP | 200 µg/ml | $322.00 | |||
β-Amyloid Antibody (D-11) FITC | sc-374527 FITC | 200 µg/ml | $336.00 | |||
β-Amyloid Antibody (D-11) PE | sc-374527 PE | 200 µg/ml | $349.00 | |||
β-Amyloid Antibody (D-11) Alexa Fluor® 488 | sc-374527 AF488 | 200 µg/ml | $364.00 | |||
β-Amyloid Antibody (D-11) Alexa Fluor® 546 | sc-374527 AF546 | 200 µg/ml | $364.00 | |||
β-Amyloid Antibody (D-11) Alexa Fluor® 594 | sc-374527 AF594 | 200 µg/ml | $364.00 | |||
β-Amyloid Antibody (D-11) Alexa Fluor® 647 | sc-374527 AF647 | 200 µg/ml | $364.00 | |||
β-Amyloid Antibody (D-11) Alexa Fluor® 680 | sc-374527 AF680 | 200 µg/ml | $364.00 | |||
β-Amyloid Antibody (D-11) Alexa Fluor® 790 | sc-374527 AF790 | 200 µg/ml | $364.00 | |||
β-Amyloid (D-11) Neutralizing Peptide | sc-374527 P | 100 µg/0.5 ml | $69.00 |