beta-Amyloid Antibody (20.1): sc-53822

β-Amyloid Antibody (20.1) is a mouse monoclonal IgG2b kappa light chain antibody that detects β-Amyloid of human origin through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). β-Amyloid (20.1) antibody is available in non-conjugated form and various conjugates, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® options. β-Amyloid, produced through proteolytic cleavage of amyloid precursor protein (APP), is crucial in Alzheimer′s disease pathogenesis, forming neurotoxic plaques in the brain. β-Amyloid (20.1) monoclonal antibody recognizes a protein significant in neurodegenerative diseases and metabolic disorders, with amyloid deposits linked to type II diabetes and Down syndrome. β-Amyloid presence in human platelets highlights broader physiological and pathological roles. APP undergoes alternative splicing to produce various isoforms, adding complexity to function and regulation. The 4 kDa β-Amyloid peptide formation contributes to neurofibrillary tangles and senile plaques development in Alzheimer′s disease. Interactions with structurally similar proteins like APLP1 and APLP2 demonstrate complex protein networks influencing amyloid-related conditions.

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beta-Amyloid Antibody (20.1) References:

1. Membrane-disordering effects of beta-amyloid peptides.  |  Müller, WE., et al. 2001. Biochem Soc Trans. 29: 617-23. PMID: 11498039
2. Multivalent & multifunctional ligands to beta-amyloid.  |  Kim, Y., et al. 2009. Curr Pharm Des. 15: 637-58. PMID: 19199987
3. The role of β-amyloid peptide in neurodegenerative diseases.  |  Maltsev, AV., et al. 2011. Ageing Res Rev. 10: 440-52. PMID: 21406255
4. Dangerous liaisons between beta-amyloid and cholinergic neurotransmission.  |  Govoni, S., et al. 2014. Curr Pharm Des. 20: 2525-38. PMID: 23859550
5. Clearance of beta-amyloid in the brain.  |  Ueno, M., et al. 2014. Curr Med Chem. 21: 4085-90. PMID: 25312211
6. β-sheet interfering molecules acting against β-amyloid aggregation and fibrillogenesis.  |  Francioso, A., et al. 2015. Bioorg Med Chem. 23: 1671-83. PMID: 25769517
7. Relationship Between Tau, β Amyloid and α-Synuclein Pathologies.  |  Walker, L. and Attems, J. 2019. Adv Exp Med Biol. 1184: 169-176. PMID: 32096037
8. Impaired occipital cerebrovascular reactivity as a biomarker for vascular β-amyloid.  |  Schreiber, S. and DiFrancesco, JC. 2020. Neurology. 95: 415-416. PMID: 32641536
9. NLRP3 and Infections: β-Amyloid in Inflammasome beyond Neurodegeneration.  |  Sita, G., et al. 2021. Int J Mol Sci. 22: PMID: 34209586
10. Nanomaterials for Modulating the Aggregation of β-Amyloid Peptides.  |  Huang, Y., et al. 2021. Molecules. 26: PMID: 34299575

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-β-Amyloid Antibody (20.1) has 15 citations in a variety of scientific publications.

Primary antibodies like Anti-β-Amyloid Antibody (20.1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

β-Amyloid Antibody (20.1) Specifications

Alternate Product Name: APP fragment Amyloid A4 1-40

Product Clone Name: 20.1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-40

Epitope Target: β-Amyloid

Epitope Species: human

Product Reactivity/Detection: APP and β-Amyloid

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 15 citations in various scientific publications

Available Conjugates/Forms for β-Amyloid Antibody (20.1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred β-Amyloid antibody is β-Amyloid Antibody (B-4): sc-28365.