beta Actin Antibody (AC-15): sc-69879

β-Actin Antibody (AC-15) is a mouse monoclonal IgG1 antibody raised against a slightly modified synthetic peptide corresponding to cytoplasmic β-Actin, capable of detecting β-Actin from a broad range of species by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). β-Actin is a highly conserved protein that plays a critical role in maintaining cell structure and integrity, serving as a principal component of the cytoskeleton and participating in various cellular processes such as cell motility, division, and signal transduction. β-Actin often constitutes up to 50% of total cellular protein in eukaryotic cells and forms both stable and dynamic filamentous structures essential for functions like the formation of microvilli and muscle contraction. β-Actin interacts with a variety of proteins, including myosin for muscle contraction and actin-binding proteins such as profilin, cofilin, and gelsolin, which regulate actin filament polymerization and depolymerization. β-Actin also associates with the Arp2/3 complex to facilitate the nucleation of new actin filaments and interacts with small GTPases like Rho, Rac, and Cdc42 that regulate cytoskeletal dynamics; Rho controls the assembly of actin stress fibers and focal adhesions, Rac promotes actin filament accumulation at the plasma membrane, and Cdc42 stimulates the formation of filopodia. Anti-β-Actin antibody (AC-15) is an invaluable tool for researchers studying actin dynamics, cell structure, and related processes across various species.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-beta Actin Antibody (AC-15) has 1,304 citations in a variety of scientific publications.

Primary antibodies like Anti-beta Actin Antibody (AC-15) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

beta Actin Antibody (AC-15) Specifications

Alternate Product Name: β-Actin

Product Clone Name: AC-15

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: cytoplasmic β-Actin

Epitope Species:

Product Reactivity/Detection: β-Actin

Species Reactivity/Detection: broad species

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1,304 citations in various scientific publications

Available Conjugates/Forms for beta Actin Antibody (AC-15): N/A

The preferred beta Actin antibody is beta Actin Antibody (C4): sc-47778.